Promotion of NLRC5 by IFN-gamma with upregulation of MHC class I (HLA-ABC) in SKBR3 breast cancer cells, suggesting the contribution to counteracting cancer evasion from immunosurveillance and benefiting cancer immunotherapy.Zhao, Ming-ZhenSun, YuJiang, Xiao-FengLiu, LiSun, Li-Xin...
在多种类型的细胞中,γ干扰素可诱导细胞因子的产生和上调不同的膜蛋白的表达,包括I/II型主要组织相容性复合体(MHC-I,MHC-II)、Fc受体、白细胞粘附分子、B7家族抗原。γ干扰素能有效活化巨噬细胞、指导B细胞免疫球蛋白的合成、类型转化和分泌。γ干扰素也能通过抑制Th2的分化和刺激Th1的生长而影响T辅助细胞亚型的...
IFNγ功能包括以下各项:抗病毒活性,肿瘤抗增殖活性,I类和II类MHC的诱导,巨噬细胞活化以及B淋巴细胞增强的免疫球蛋白分泌。 IFNγ参与细胞因子的调节,并与其他细胞因子协同作用。 IFNγ的激活是通过IFNγ受体I和II的结合并激活JAK-STAT途径进行的。 IFNγ与IFNα或IFNβ没有任何同源性,但是人IFNγ与小鼠IFNγ具有...
For an effective CD8+ cytotoxic T cell response to occur during infection, MHC class I molecules must be loaded with antigenic peptides in the endoplasmic reticulum. The cytosolic factor responsible for peptide generation is believed to be the proteasome, with the TAP heterodimer mediating peptide ...
Regulatory dendritic cells restrain NK cell IFN-gamma production through mechanisms involving NKp46,IL-10,and MHC class I-specific inhibitory receptors. SPALLANZANI R G,TORRES N I,AVILA D E,et al. J Immunol . 2015... Raúl,G.,Spallanzani,... - 《Journal of Immunology》 被引量: 16发表:...
IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. ...
upregulates the expression of class I and II MHC antigens, Fc receptor and leukocyte adhesion molecules. It modulates macrophage effector functions, influences isotype switching and potentiates the secretion of immunoglobulins by B cells. IFN-γ also augments TH1 cell expansion and may be required fo...
IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. ...
IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. ...
IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells and antigen-recognizing B and T...