然而,这些表观遗传学亚群对治疗胶质母细胞瘤患者的进一步预后意义尚不清楚。 本文中,在430例IDH-Wildtype GBM的多中心队列中发现MES亚类肿瘤患者在大体全切除或接近大体全切除的OS或PFS方面没有显著优势。相反,在RTK I和RTK II肿瘤患...
纳入诊断为IDH wild-type复发性GBM并接受pembrolizumab或nivolumab治疗的患者,研究ICIs治疗前后MRI弥散成像数据的可用性,并计算肿瘤与瘤周正常白质中位ADC相对比值。
However, this case showed that the other genetic mutations can be initiated before the IDH mutation in glioma oncogenesis. Contrary to the previous hypothesis, this is the first case of IDH-wildtype secondary glioblastoma arising in IDH-mutant diffuse astrocytoma....
Mutations in isocitrate dehydrogenases (IDH) are oncogenic events due to the generation of oncogenic metabolite 2-hydroxyglutarate. However, the role of wild-type IDH in cancer development remains elusive. Here we show that wild-type IDH2 is highly expre
Glioblastoma, IDH-wildtype remains a molecularly heterogeneous disease that is refractory to current therapies. To investigate how longitudinal epigenomic evolution of glioblastoma drives tumor progression and treatment resistance, we performed comprehensive histopathologic assessment, targeted genomic sequencing, ...
ARTICLE https://doi.org/10.1038/s41467-020-17382-3 OPEN Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution Yinghua Li 1,2,3,13, Bo Li4,13, Wei Li5,13, Yuan Wang 1,2,3, Seçkin Akgül 1,2,3,6,12, Daniel ...
TMET-11. IMPACT OF METABOLIC RISK FACTORS ON SURVIVAL IN GLIOBLASTOMA IDH-WILD TYPE doi:10.1093/neuonc/noae165.1149Altered cellular metabolism is a hallmark of cancer. Systemic metabolic dysregulation has been associated with the pathogenesis of cancer, including glioblastoma. In particular, the ...
1A and B and 87 patient-matched longitudinal samples with both primary and recurrent (surgery 1 and surgery 2) IDH wild-type (IDH-wt) GBMs were considered in this study (Additional file 1: Table S1). To minimize potential spurious events, only the genes expressed (i.e., TPM > 0...
BIOM-63. LONG-TERM SURVIVAL AND MOLECULAR CHARACTERIZATION OF IDH-WILDTYPE GLIOBLASTOMA IN AN ASIAN COHORT doi:10.1093/neuonc/noae165.0135BACKGROUND. Glioblastoma (GB), the most aggressive form of brain tumor, presents a significant clinical challenge with a devastating prognosis. Globally, the ...
Current standard of care for IDH-wildtype glioblastoma (GBM) includes maximal safe resection, adjuvant radiation, and chemotherapy with the alkylating agent temozolomide. A subset of gliomas treated with temozolomide develop somatic hypermutation with a predominance of C>T transitions due to the ...