Diffuse, IDH-wildtype gliomas in adults with minimal histological change and isolated TERT promoter mutation: not simply CNS WHO grade 4NUCLEOTIDE sequencingCHROMOSOME abnormalitiesBRAIN tumorsTUMOR classificationHEMATOXYLIN & eosin stainingPLANT chromosomesPROGRESSION-free survival...
WHO grade 4. Diffuse gliomas that areIDH-wildtype and have molecular features of GBM can now be classified as the latter, even when histological high-grade features are absent [3,53]. These molecular
BACKGROUND Isocitrate dehydrogenase (IDH)1/2 wildtype astrocytomas, classified as CNS WHO grade 4 tumors in the latest WHO classification of 2021, have high recurrence rates. The role of surgery in these tumors remains uncertain.. In this study the impact of the extent of resection (EOR) on...
The WHO (2021) Classification classified a group of pediatric-type high-grade gliomas as IDH wildtype, H3 wildtype but as of currently, they are characterized only by negative molecular features of IDH and H3. We recruited 35 cases of pediatric IDH wildtype and H3 wildtype hemispheric gliobla...
b, Patients (CGGA cohort) were grouped according to tumour source and WHO grading and the LOC expression levels of the IDH-wild-type and IDH-mutant groups were compared. WHO grade II, IDH wild-type (n = 59) and IDH mutant (n = 9); WHO grade III, IDH wild-type (n =...
The distinction between IDH-mutant vs wildtype glio- mas has also become clearer, with the omission of "sec- ondary" or IDH-mutant GBM in favor of the term diffuse IDH-mutant astrocytoma, WHO grade 4. Diffuse gliomas that are IDH-wildtype and have molecular features of GBM can now be...
We then retrospectively retrieved all cases with a histopathologically- and molecularly-proven diagnosis of “de novo” WHO grade 4 GBM, IDHwt. The pre-operative and surgical protocols used to selectively identify and sample the different tumor areas foresaw an intraoperative multimodal imaging ...