Full size image As late-stage experimental tumors were more enriched for recruited myeloid cells, we investigated functional phenotypes of monocyte-derived cells at late time points and found robust expression of the previously defined AP signature in both cell compartments (Fig. 3a)8. While DCs sh...
Full size image The above observations prompted us to investigate the potential mechanisms by which IDH2 abrogation caused α-KG elevation. We used [U13C]-labeled glutamine as a tracing agent to analyze the metabolic flow in the IDH2-inhibited cells in comparison with the control cells harboring...
Full size image NF1 alterations were mutually exclusive with alterations in EGFR (log2OR –2.3, p-adj < 0.001), MDM2 (log2OR –2.5, p-adj = 0.05), PDGFRA, and CDK4 (Fig. 1B, Supplementary Table 2). Alterations in NF1 co-occurred with alterations in PIK3R1 (log2OR 1.6...
Full size image To verify whether the changes in GM-CSF, LIF, and OSM expression were related to IDH2/R140Q mutation in TF-1(R140Q) cells, we investigated the effect of AGI-6780 on the mRNA expression and protein secretion of GM-CSF, LIF, and OSM. We found that AGI-6780 treatment...
The compelling efficacy results observed with vorasidenib in the INDIGO study underscore its full potential to emerge as the benchmark treatment for patients grappling with IDH-mutant diffuse glioma harboring IDH1/2 mutations," stated Claude Bertrand, Executive Vi...
Full size image Fig. 2 showed a 42-year-old male glioma patient with IDH-1(+) and Ki-67 of 5%. Ktrans (A), Ve (B), and APTW (C) showed irregular lesions in the left cerebellar hemisphere, the solid part of the tumor was low signal in the corresponding sequence. ADC (D) showe...
All fieldsTitleAbstractKeywordsAuthorsAffiliationsDoiFull TextReferences Open AccessArticle by Susanna Grassi 1,*,†, Francesca Guerrini 1,†, Elena Ciabatti 1, Riccardo Puccetti 1, Serena Salehzadeh 1, Maria Rita Metelli 2, Alessia Di Vita ...
Subfield$w/0-Print constant code[redefined, 1997][CAN/MARC only]: The following values were redefined:g(Full name),h(Real name), andi(Real name (reputedly)). The following values were made obsolete:j(Name originally),k(Name in religion),l(Secular name),m(Stage name of),o(Variant nam...
3.8. Insulating sheets are installed in the front and rear covers of the hot plate of this machine. Three, payment method: spot supply, delivery can be made when the payment is received, and a full value-added tax invoice will be issued ...
Full size image Dynamic susceptibility contrast MRI measures cerebral blood volume (CBV), a surrogate marker of total tumor vascularity. In contrast, dynamic contrast-enhanced MRI measures the permeability surface area which reflects the leakiness of vasculature [17]. Both parameters may differentiate ...