Nomograms have emerged as a valuable tool for predicting the prognosis of cancer owing to their ability to integrate statistical predictive models into a singular numerical estimate of the probability of an event, such as mortality or relapse, which is specifically customized to individual patient att...
Background: Driver mutations are traditionally considered as actionable biomarkers for targeted drugs, but the resistance and relapse effects often occur even when these events are precisely discovered. At the same time, primary DNA mutations can be only the triggers for cell malignancy and further ...
The cellular reprogramming induced by drugs might transform the cells from a drug-resistant state into a drug sensitive state, suggesting potential strategies to forestall future tumor relapse. Developing novel therapeutic agents is critical for improved TNBC therapies. Genomic-based analysis helps to ...
2,283 Views 0 CrossRef citations to date 0 Altmetric Listen Research Paper Identifying the location-dependent adipose tissue bacterial DNA signatures in obese patients that predict body weight loss Matthieu Minty, Alberic Germain, Jiuwen Sun, Gracia Kaglan, Florence Servant, Benjamin Le...
For example, molecular mimicry can trigger activation of autoreactive T lymphocytes while superantigens can reboot autoreactive T cells, thus inducing relapses [114]. Of all NADs, the ones studied the most in terms of infectious etiology are MS, GBS, MG, and NMO. Download: Download full-...
N-methylpurine DNA glycosylase, known to be expressed in breast cancer, triggers DNA strand breaks in response to alkylating agents by increasing abasic sites. Although these lesions induced p53-dependent growth arrest and were effectively repaired in p53-proficient cells, they were repaired at ...
In a particularly preferred embodiment, the patient is undergoing an immunotherapy that aims to treat an allergy, preferably the immunotherapy is a desensitization therapy, the immunotherapy aims to (i) reduce the immune response against the allergen(s) which trigger(s) the allergy and/or (ii) ...
Although new agents are implemented to cancer therapy, we lack fundamental understandings of the mechanisms of chemoresistance, the main obstacle to cure in cancer. Here we review clinical evidence linking molecular defects to drug resistance across different tumour forms and discuss contemporary experimen...
(NADW). The origin of this bottom current relapse, on a large scale, in convection cells in the Labrador Sea and Norwegian Greenland Sea [14] and enters the Icelandic basin as an arm of the Deep Northern Boundary Current, which affects the western slope of the Hatton Bank and presents ...