In response, PCCs produce AREG, which triggers the Hippo-YAP signaling pathway in macrophages, leading to the secretion of CCL5. Therefore, the macrophage-CCL5-Sp1-AREG loop is formed between macrophages and PCCs in the microenvironment. Targeting this loop with drugs like maraviroc, mithramycin...
For example, molecular mimicry can trigger activation of autoreactive T lymphocytes while superantigens can reboot autoreactive T cells, thus inducing relapses [114]. Of all NADs, the ones studied the most in terms of infectious etiology are MS, GBS, MG, and NMO. Download: Download full-...
N-methylpurine DNA glycosylase, known to be expressed in breast cancer, triggers DNA strand breaks in response to alkylating agents by increasing abasic sites. Although these lesions induced p53-dependent growth arrest and were effectively repaired in p53-proficient cells, they were repaired at ...
Another gene of potential interest is cell division cycle 25 homolog C (CDC25C), a critical gene involved in cell division that dephosphorylates cyclin B-bound CDC2 (CDK1) and triggers entry into mitosis [37]. It might also have a role in suppressing p53-induced growth arrest and has ...
Nomograms have emerged as a valuable tool for predicting the prognosis of cancer owing to their ability to integrate statistical predictive models into a singular numerical estimate of the probability of an event, such as mortality or relapse, which is specifically customized to individual patient att...
triggers DNA strand breaks in response to alkylating agents by increasing abasic sites. Although these lesions induced p53-dependent growth arrest and were effectively repaired in p53-proficient cells, they were repaired at poor efficiency in cells mutated forTP53, subsequently leading to cell death....
Background: Gender-affirming treatments are reported to improve mental health significantly. However, a substantial number of transgender individuals report a relapse in, or persistence of, mental health problems following gender-affirming treatments. This is due to multiple stressors occurring during this...
Plasmacytoid dendritic cells (pDCs) represent a unique subset of DCs that trigger the production of large amounts of type I interferons after viral infections. Additionally, toll-like receptors (TLR7 and TLR9) on pDCs were shown to directly kill breast cancer cells through TNF-related apoptosis-...