Based on the CMap database, ten key genes were used to search for potential drugs for IgAN treatment and the top ten candidate drugs were identified. Among these drugs, only cortisone, which belongs to corticosteroids and acts as one of existing immunosuppressive options, has been extensively use...
Although this disease is irreversible, we can identify the disease in its early stage and take intervention measures on environment and drugs to slow down the progression of the disease. Most of the existing studies on Alzheimer's disease are based on medical images. With the development of ...
dependent on the cell source (Basler et al.2013; Kloetzel2004). The manner by which proteins are cleaved to form short peptides capable of binding to the MHC molecules has been examined. This has largely
Virtual Screening of an FDA Approved Drugs Database on Two COVID-19 Coronavirus Proteins (2020) Google Scholar [25] C. Wu, Y. Liu, Y. Yang, P. Zhang, W. Zhong Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods Acta Pharm. Sin. B...
[26,27]. A negative connectivity score indicates the drugs may be candidates for the treatment of diseases by reversing the specific gene expression pattern in disease states. These ten hub genes were submitted to the CMap database to predict potential therapeutic drugs ameliorating IgAN prognosis....
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Lost but making progress—where will new analgesic drugs come from? Sci. Transl. Med. 6, 249sr3 (2014). Article Google Scholar LeDoux, J. E. & Pine, D. S. Using neuroscience to help understand fear and anxiety: a two-system framework. Am. J. Psychiatry 173, 1083–1093 (2016). ...
Also, when examining the genes affected by cocaine, many were related to cellular activity. Drugs of abuse are not suggested as a possible treatment for depression, but an understanding of how they might interact with depression opens the possibility of targeting specific pathways in developing new...
Though at this point you're likely too sore to identify any actual injury, and they're just going to prescribe rest and painkillers/anti-inflammatory drugs.Assuming that you have the sense that you're in pain but not injured per se, I'd focus on decreasing inflammation, and giving it a...
Not surprisingly then, MT polymerization is stimulated by the stretching of cells [21]. The αβ-tubulin dimer subunit structure has been the target of drugs (colchicine, vinblastine, taxanes, epothilones) designed to bind specific sites on these subunits, leading to arrest of rapid cell growth...