Novel technological developments can simultaneously measure thousands of human proteins in a single blood sample. The SOMAscan V4 assay includes 5207 aptamers capable of measuring 4988 unique human proteins, of which 514 are the target of drugs licensed or in the clinical phase, 1153 are the target...
The epithelial-mesenchymal transition (EMT) has been implicated in conferring stem cell properties and therapeutic resistance to cancer cells. Therefore, identification of drugs that can reprogram EMT may provide new therapeutic strategies. Here, we repo
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Novel technological developments can simultaneously measure thousands of human proteins in a single blood sample. The SOMAscan V4 assay includes 5207 aptamers capable of measuring 4988 unique human proteins, of which 514 are the target of drugs licensed or in the clinical phase, 1153 are the target...
Given the success of PCSK9 in treating CHD, we demonstrate that FES may be a novel therapeutic target. Future work should aim to validate and develop drugs based on these potential targets.Data availability 1871cis pQLTs of 1850 plasma proteins from the published article by Sun et al. (Sun...
As DNA demethylating agents have been associated with increased antigen processing and presentation [65], a combination therapy of epigenetic drugs with peptide vaccination might overcome the limitations of both as single therapies. Moreover, somatic mutations in candidate genes could be exploited in ...
Targeting zinc homeostasis shows potential for developing antifungal drugs. Zinc-attenuating compounds, such as ZAC307 and ZAC989, have been identified and demonstrated antifungal activity by chelating zinc in vitro [131]. These compounds have also shown efficacy in murine fungal infection models, indic...
R Gupta,PI Murray - 《Drugs & Aging》 被引量: 68发表: 2006年 [Characteristics of uveitis presenting de novo in the elderly]. This study aimed to describe the clinical characteristics of uveitis presenting de novo in the elderly. The study design was a description of a retrospecti... O ...
genes given by the SNP2GENE function to the drug database (DrugBank88) via the GENE2FUNC function in the FUMA platform. The gene table mapped to the DrugBank database provides gene information and the relevant DrugBank IDs that can be found athttps://go.drugbank.com/drugswith the details....
2c, Table 1, and Supplementary Data 1), suggesting these drugs, if they were to prove efficacious in vivo, could potentially be co-administered with remdesivir to increase the overall safety and efficacy of treatment, while limiting the evolution of drug resistance. High-throughput Calu-3 ...