The use of gene function to identify the rate-limiting steps controlling cell fate. Cancer Immunol Immunother 2004; 53:160-5.Williams GT, Farzaneh F. The use of gene function to identify the ratelimiting steps controlling cell fate. Cancer Immunol Immunother. 2004; 53 :160–165. doi: ...
verification of a drug resistance gene in the Apicomplexan parasite Toxoplasma gondii, the method of Quantitative Trait Locus (QTL) mapping using a Whole Genome Sequence (WGS) -based genetic map and the method of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 -based gene ...
resultsCompiles the final results of chimeric transcripts incorporating inputs from previous steps Commands and options Star The first step in the FREDY’s pipeline is the “star”. The inputs to this command are FASTQ files and a STAR index (pre-made availablehere). The output is a sorted...
Reagan W. Ching2, Rachel Cotton1, Ren Li1 & David P. Bazett-Jones1 Gene loci make specific associations with compartments of the nucleus (e.g. the nuclear envelope, nucleolus, and transcription factories) and this association may determine or reflect a mechanism of genetic contro...
Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex. J Biol Chem. 2001;276:20633–40. Article CAS PubMed Google Scholar Kataoka T, Budd RC, Holler N, Thome M, Martinon F, Irmler M, et al. The ...
DE, differential expression; HpSp, Hippocampal sparing; Limbic, limbic predominant; RNA-Seq, RNA sequencing. Note: Numbers in boxes represent total gene number from each part of workflow. Steps 1–3 culminated in 339 unique genes, of which 19 overlapped in one or more of the steps. *In St...
The possibility that synonymous mutations might be enriched in cancer has been explored in several recent studies. However, none of these studies control for all three types of mutational heterogeneity (patient, histology, and gene) that are known to affect the accurate ...
pear self-incompatibility S-genotype cDNA microarray oligonucleotide gene chip 1. Introduction Pears (Pyrus) are typical gametophytic plants that show self-incompatibility, which is controlled by multiple alleles of a single S-locus. The gene product of the pear S-locus has been identified in the ...
Pre-mRNA splicing is a key controller of human gene expression. Disturbances in splicing due to mutation lead to dysregulated protein expression and contribute to a substantial fraction of human disease. Several classes of splicing modulator compounds (SMCs) have been recently identified and establish ...
Triple negative breast cancer (TNBC) is defined as lacking the expressions of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). TNBC patients exhibit relatively poor clinical outcomes due to lack of