Explain the process of mitosis. Discuss the stages of mitosis. Describe the events that occur in the four phases of mitosis (prophase, metaphase, anaphase and telophase). (a) Describe the primary events that take place at each stage of mitosis and meiosis. (b) Compare mitosis and me...
To better understand the functional state of NK cells, we used Monocle 2 to determine their developmental trajectory. Pseudo-time analysis showed that NK cells were divided into different stages on the time trajectory (Fig. 6C), that is, different functional states. ResponseScore grouping can ...
Host anti-viral factors are essential for controlling SARS-CoV-2 infection but remain largely unknown due to the biases of previous large-scale studies toward pro-viral host factors. To fill in this knowledge gap, we perform a genome-wide CRISPR dropout screen and integrate analyses of the mult...
Stem cells within these zones are in a process of continuous renewal. They also generate the precursor cells that subsequently divide and differentiate to form all the specialized cells within the plant. A centrally located group of organising stem cells (four in Arabidopsis) within the RAM form ...
Embryonic development of the cerebral cortex: a primer. The development of the cerebral cortex can be divided into several stages (see figure). 1.Patterning: The basic plan of the mammalian brain is laid out at the neural plate stage. At this stage, signaling centers that surround the neural...
These early stages of brain development are highly dynamic. One could hypothesize that small changes dur- ing these processes could lead to larger effects later. Key stages of brain development at which ASD-related genes may act are described in Fig. 1. Studying human prenatal brain development ...
of peripheral blood mononuclear cells (PBMCs). We integrated these data to provide a comprehensive view of the COVID-19 multi-omic landscape, enabling us to link transcriptomic and cellular changes with circulating proteins. Supervised learning identified plasma levels of the LRRC15 protein, a ...
We validated on an inde- pendent cohort of samples five genes by quantitative real- time PCR that are expressed in germ cells or the somatic compartment and which are exclusively altered by the presence of YCMD. We conclude that the deletion of Y-chromosomal genes has a significant effect on...
Arrest of segregation leads to accumulation of highly intertwined catenated dimers: dissection of the final stages of SV40 DNA replication. When SV40-infected cells are placed into hypertonic medium, newly synthesized DNA accumulates as form C catenated dimers. These molecules consist of two su... ...
1f), likely reflecting reduction of PARP1 localization and activity after the initial stages of DNA repair. The binding of the biosensor to the microirradiated site was rapid and reversible as shown by FRAP experiments (Supplementary Fig. 1c). To confirm the specificity of this effect, we ...