Though the roles of oxidative phosphorylation and glycolysis are defined in AML, the role of the hexosamine biosynthetic pathway (HBP), which regulates the OGlcNAcylation of cytoplasmic and nuclear proteins, remains poorly defined. Methods: We studied the expression of the ke...
Table S1. Summarized clinical demographics of the discovery cohort, related to Figure 1 and STAR Methods Table S2. Differential plasma and fecal metabolites along the adenoma-carcinoma sequence, related to Figure 2 and Figure S1 Table S3. Overlapped plasma and fecal metabolites and differential gut...
6b). Only the validation of PKM (pyruvate kinase M1/2) was divergent from the screen, most likely caused by direct cytotoxicity due to impaired glycolysis, resulting in lower adhesion levels upon PMA-stimulation than expected, and by competitive outgrowth of PKM-proficient cells (due to in ...
Most cells within day 44 cortical organoids were associated with glycolysis compared to just 2% in the fetal cortex, suggesting that organoid cells are metabolically stressed [1]. This ab- normal rate of glycolysis could mask effects caused by ASD-causing mutations as studies have shown elevated ...
Perhaps the most physiology-relevant of these interactions is with the tricarboxylic acid cycle enzyme aconitase. This enzyme is a sensitive target in the mitochondrial matrix. The superoxide-dependent inactivation of this enzyme leads to enhanced glycolysis relative to oxidative phosphorylation in cellular...
glycolysis, fatty acid degradation and TCA cycle. The time-series analysis predicted the cell differentiation of 15 clusters with 13 cell types. The results indicated that, starting from CRCSCs, the main differentiation trajectories led towards cancer cells and fibroblasts (Fig.3H,I), the results ...
The enriched pathways included electron transport chain (ETC), fatty acid metabolism, glycolysis, oxidative phosphorylation, ROS, the pentose phosphate pathway (PPP), cell death, fatty acid beta-oxidation, TCA cycle, fructose metabolism, glutathione, and the ERK 1, ERK 2, MAP kinase pathways. ...
then the pathway as a whole is likely to be causal even if some of the gene signals were false positives. The primary inputs for MSEA include 1) marker to disease association statistics, where markers can be SNPs from GWAS, genes or transcripts from microarrays or RNA sequencing, epigenetic...
First, discriminant analysis identified that fatty acid oxidation and intracellular triglyceride accumulation were the most relevant in differentiating the cytotoxic phenotype. Second, gene set enrichment analysis (GSEA) was applied to the cDNA microarray data to identify the transcriptionally altered pathways...
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