Diagram of the glycolysis/pentose pathway indicating the 7 downregulated proteins in CFNP.Ludovic JeansonIda Chiara GuerreraJeanFrançois PaponCerina ChhuonPatricia ZadigueVirginie PrulièreEscabasseSerge AmselemEstelle EscudierAndré CosteAleksander Edelman...
Glycolysis | Pathway, Steps & Products6:44 Krebs Cycle | Definition, Steps & Products5:58 Electron Transport Chain | Diagram, Products & Steps6:16 Lactic Acid vs. Alcoholic Fermentation | Process & Examples6:25 Glycolysis & the Citric Acid Cycle6:30 ...
Mechanistic investigations revealed that ALB remarkably attenuated TGF-β1 induced aerobic glycolysis in fibroblasts via activation of the LRRN3/PFKFB3 signaling pathway (Fig. 8), consistent with its known ability to reprogram glucose metabolism [13]. Fig. 8 Schematic diagram for the mechanisms of ...
NMNAT2 catalyzes NAD synthesis in the salvage pathway, the major pathway in CNS neurons for NAD biosynthesis [15]. The ratio of oxidized (NAD+) to reduced (NADH) forms of NAD establishes the NAD redox potential (NAD+/NADH) and is crucial to driving glucose metabolism [82, 83]. To deter...
attenuated TGF-β1 induced aerobic glycolysis in fibroblasts via activation of the LRRN3/PFKFB3 signaling pathway (Fig.8), consistent with its known ability to reprogram glucose metabolism [13]. Fig. 8 Schematic diagram for the mechanisms of albendazole in fibroblasts. TGF-β1 treatment ...
S4G, H). Taken together, these findings suggest that circME1-ME1 pathway plays critical roles in sunitinib resistance development and aerobic glycolysis of ccRCC cells. Discussion Anti-angiogenic drugs, such as sunitinib, have been developed for RCC therapy, based on the frequent inactivation of ...
Mechanistically, CXCR4, a chemokine receptor, when silenced, weakens the PI3K/AKT/mTOR pathway as its downstream signal, reducing c-MYC expression. PFKFB3, a key enzyme involved in glucose metabolism, is a target gene of c-MYC, thus impacting macrophage polarization and glycolytic metabolism ...
Current insights reveal that glycolysis activity in tumor cells would generate D-fructose-6-phosphate intermediate product to synthesize UDP-GlcNAc through hexosamine biosynthetic pathway (HBP), which is the canonical glycan donor for glycosylation of proteins22,23. Meanwhile, hyperglycolytic tumor cells...
LncRNA OIP5-AS1 promotes the malignancy of pancreatic ductal adenocarcinoma via regulating miR-429/FOXD1/ERK pathway. Cancer Cell Int. 2020;20:296. Article CAS PubMed PubMed Central Google Scholar Yu H, Xu A, Wu B, Wang M, Chen Z. Long noncoding RNA NEAT1 promotes progression of ...
pathway and changes in the c-Myc protein level in prostate tissue.EImmunofluorescence staining analysis of the co-localization of F4/80/Pfkfb3 in prostate tissue.FSchematic diagram illustrating how CXCR4 influences c-Myc transcriptional regulation of Pfkfb3, leading to metabolic changes in macrophages...