product has been shown to inter- act with islet antigen-2, a transmembrane protein tyrosine phosphatase associated with dense core secretory vesicles and a major autoantigen in type 1 diabetes.29 The functions of the other three genes are related to aspects of cytoskeletal organi- zation and ...
Identify the following: A hormone secreted by the thymus which stimulates the red bone marrow to produce T-cells. Lymphatic System The lymphatic system is a network of specialized valved vessels that drain interstitial fluid (lymph). The lymphatic system is ...
In addition, pathway analysis highlights the prominent role of MS genes in activation of platelets and coagulation system in tumor metastatic cascade. Moreover, global mutation pattern of MS genes across multiple cancers may reveal common cancer metastasis mechanisms. All these results illustrate the ...
(8-‐13) Trafficking mechanisms associated with the platelet lifecycle include endocytosis /pinocytosis by megakaryocytes, phagocytosis of platelets by macrophages in the spleen, and secretion of platelet ...
Selective vulnerability of different brain regions is seen in many neurodegenerative disorders. The hippocampus and cortex are selectively vulnerable in Alzheimer’s disease (AD), however the degree of involvement of the different brain regions differs a
The cell surface receptor SLAM controls T cell and macrophage functions J. Exp. Med., 199 (2004), pp. 1255-1264 View in ScopusGoogle Scholar 33 J. Polgár, S.H. Chung, G.L. Reed Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are requir...
20 PCs and 30 neighbors were used to run UMAP, diffusion map, and FDG functions. Megakaryocyte signature genes (Table S5) were superimposed on the UMAP, diffusion map and FDG. Identifying patters of expression of transcription factor genes along megakaryocyte and erythroid trajectories in ...
changes in gene expression can be inferred. These coordinated changes are valuable in understanding the factors involved in disease and the functions of many poorly studied genes. One of the issues that arises with these large-scale datasets, however, is that it becomes harder to interpret the da...
Moreover, we found a genome-wide pleiotropy between lower levels of an accessory subunit of voltage-gated potassium channels, KCNE2, and migraine risk. Interestingly, potassium channels with a variety of biological functions (e.g., regulating neurotransmitter release) have been linked to migraine ...
In this study, the top 10 neurons were selected at each layer. Instead of the traditional polynomial function widely used in the GMDH network, a matrix of nonlinear non-convex functions including exponential, sinusoid, and logarithmic forms was used to model the interaction. Thus, the PSO algori...