8 However, the prescribing of appropriate polypharmacy in the elderly remains a complex issue and much work has been undertaken to classify specific drug classes or individual drugs which may be particularly pr
During drug development, it is essential to gather information about the change of clinical exposure of a drug (object) due to the pharmacokinetic (PK) drug-drug interactions (DDIs) with another drug (precipitant). While many natural language processing (NLP) methods for DDI have been published...
After averaging the four or five replicates per compound, this resulted in 132 classifications, with 129 being correct. Belinostat was incorrectly classified as a mercurial, when entinostat was left out and vice versa. PMA was classified as HDACi when mercury(II)bromide was left out (Fig. 5b)...
The classifications were not dependent on the classification method since similar results were obtained using 20 different methods (Additional file 2). As an example, the AUC for breast cancer was 1, p = 10−4. An independent validation study in 24 breast cancer patients and 14 healthy sub...
20 The codes were specified based on the American Pain Society Taxonomy5 and classifications developed by Health Care System Research Network investigators,16 Veterans Health Administration (VHA) researchers,7, 9 and diagnostic clusters in the Ambulatory Care Group System.17, 21 Next, we merged ...
TDF/FTC is a medication that is also used for HIV treatment in combination with other antiretroviral medications, can also be used in regimens for postexposure prophylaxis (PEP), and is sometimes prescribed off-label as for the management of chronic hepatitis B (CHB). For these reasons, to ...
determine HRV and RRV from HR and RR respectively, and HR and RR may be calculated from ECG leads, such as the same three lead ECG leads. Therefore, the present invention represents a minimal requirement approach for data collection to be able to generate significant classifications of body ...
For emotion classifications, eight emotions have been considered, as proposed by Clynes [49]. These emotions and profile information used for their examination has been described in Table 5. Int. J. Environ. Res. Public Health 2018, 15, 2907 12 of 24 The emotional states have been identified...
Variant classifications, databases and genotype-phenotype correlations. Arch. Pediatr. 2020, 27, eS13–eS18. [Google Scholar] [CrossRef] Sosnay, P.R.; Salinas, D.B.; White, T.B.; Ren, C.L.; Farrell, P.M.; Raraigh, K.S.; Girodon, E.; Castellani, C. Applying Cystic Fibrosis...
dissociative disorders, and hundreds more. It also clarifies common terminology, such as autism spectrum and gender dysphoria, to create clarity across the many branches of psychology. However, the DSM is not the only diagnostic tool available, and many therapists treat symptoms individually. If you...