The antigen presenting cells are used to generate monoclonal antibodies. The monoclonal antibodies may be screened by cloning the same fragments into a display vector containing a transmembrane domain thereby displaying the expressed proteins on the surface of a host cell. The monoclonal are screened ...
Firstly, they found that antigen presenting cells were behaving differently. Normally, antigen presenting cells take up dengue virus particles, cut them up into smaller pieces, and show these virus fragments to the rest of the body as a warning of infection. Secondly, B cells became heavily infe...
(1) BTN3A2 can mediate the activation of γδ T cells and activate Vγ9Vδ2 T cells through phosphoantigen (PAg)43,46. Through the antigen-presenting cell properties of Vγ9Vδ2 T cells, γδ T cells can stimulate αβ T cell activation and proliferation, promote the release of ...
Using a laboratory technique created at Johns Hopkins Medicine in 2010, the study researchers replicated the cellular environment in which specialized immune cells called antigen presenting cells (APCs) break down proteins derived from HIV and make them visible ("presented") to the immune system's f...
aeruginosa , and mouse macrophage galactose-type lectin (mMGL-2), a protein expressed on antigen presenting cells that may be useful as a vaccine targeting receptor. An advantage of the approach is that structural information about the lectin/receptor is not required to obtain a multivalent ...
The waxy cell wall of Mtb contains many unique lipids that are recognized by human T cells when bound to conserved CD1 molecules at the surface of antigen-presenting cells (Beckman et al., 1994). Sulfoglycolipids (SGLs) are a family of cell wall lipids found only in Mtb that consist of...
Deciphering the signaling pathways that govern stimulation of nave CD4+ T helper cells by antigen-presenting cellsviaformation of the immunological synapse... S Faley,K Seale,J Hughey,... - 《Lab on A Chip》 被引量: 157发表: 2008年 Cryptosporidium propidium monoazide-PCR, a molecular biology...
For priming, 1 × 106 T cells were incubated with 2 × 105 artificial antigen-presenting cells (aAPCs) coated with HLA-bound peptides (donor-matched HLA:peptide monomers, in-house production) and α-CD28 in the presence of 5 ng/ml IL-12 (PromoCell) as previously described [...
Low expression might limit the uptake by professional antigen-presenting cells and thus also limit the priming of naive T cells in vivo through cross presentation. Similarly, the engagement of CD4+ T helper cells through HLA class II presentation might also be limited. Nevertheless, tumor-specific...
fragments of proteins from within the cell on the cell surface, effectively "presenting" them to the immune system, which is constantly scanning the body for foreign or toxic antigens. When foreign peptides are identified, they trigger a cascade that allows cytotoxic T cells to eliminate ...