The controls were from 10 months to 10 years of age, and their male-to-female sex ratio was 11:3. Other patient characteristics are depicted in Tables 1 and 2. Table 1 Information on patients included in the study. Full size table Table 2 Additional information on participants from the ...
where it regulates proteins involved in calcium handling, excitation-contraction coupling, activation of hypertrophy, cell death, and inflammation22. Several case-control studies have shown an upregulation of cardiac CamKII-δ expression
Diseases or characteristics statistically significant with causal proteins are labeled Full size image Enrichment analysis of causal proteins and construction of PPI networks In the DO enrichment analysis, the causal proteins for CHD and MI were strongly enriched in MI, familial hyperlipidemia, familial ...
where it regulates proteins involved in calcium handling, excitation-contraction coupling, activation of hypertrophy, cell death, and inflammation22. Several case-control studies have shown an upregulation of cardiac CamKII-δ expression
Crossref PubMed Google Scholar 4. Diaz-Arrastia R, Kochanek PM, Bergold P,et al.: Pharmacotherapy of traumatic brain injury: state of the science and the road forward: report of the Department of Defense Neurotrauma Pharmacology Workgroup.J Neurotrauma2014;31:135–158. ...
Therapeutics used in the treatment of diabetic nephropathy The hyperglycemic condition initiates multifactorial events that damage the kidney structurally and functionally such as glomerular hyperfiltration, epithelial hypertrophy, proteinuria, following thickening of the glomerular basement membrane, mesangial matri...
N-terminal pro-brain natriuretic peptide: a powerful predictor of mortality in hypertension. Natriuretic peptides are controregulatory hormones associated with cardiac remodeling, namely, left ventricular hypertrophy and systolic/diastolic dysfunct... V Paget,L Legedz,N Gaudebout,... - 《Hypertension》...
but without an activated renin-angiotensin system.We argue that markers of an activated renin-angiotensin system, such as left ventricular dysfunction, left ventricular hypertrophy, renal dysfunction, as assessed by estimated glomerular filtration rate, or urinary albumin excretion, may be used as target...
be attributed to the characteristics of their target proteins8. Hence, these potential discriminating properties can be identified and exploited to predict novel drug targets (DT). Based on this assumption, several classic machine learning algorithms have been utilized for feature selection and DT predi...
Mhrt functions in the pathogenesis of cardiomyopathy including hypertrophy and heart failure15. A highly conserved lncRNA NORAD functions in maintaining genome stability by sequestering PUMILIO proteins16. Despite these notable examples, the function of most lncRNAs remains unknown, and it has been ...