This cross-protection could be similar to that observed between human coronaviruses causing the common cold and SARS-CoV-2. The limited numbers observed in the proteomes of FCoV, MCoV, and SW1-CoV may offer an explanation for the susceptibility of cats and minks to SARS-CoV-2, as well ...
Ginsberg MH, Loftus J, Ryckwaert J-J, Pierschbacher M, Pytela R, Ruoslahti E, Plow EF: Immunochemical and amino-terminal sequence comparison of two cytoadhesins indicates they contain similar or identical / subunits and distinct a subunits. J Biol Chem 1987;262:5437-5440...
The filament is a helical tubular assembly of a single protein, FliC or flagellin, with a diameter of 10–20 nm, and a few tens of thousands of subunits build a helical propeller that grows up to 10–15 μm long. Its ability to switch between polymorphic, left- and right-handed ...
This exotoxin is a multimeric, 105 kDa protein, composed of five subunits arranged in a typical A–B structure9. In this holotoxin, the A-domain contains the enzymatically active S1 subunit while the B-oligomer, responsible for the binding to receptors on target cells, consists of two ...
All sequenced genomes of representatives of the Francisella genus contain two rpoA genes, which encode non-identical RNA polymerase (RNAP) subunits, α1 and α2. In all other bacteria studied to date, a dimer of identical α subunits initiates the assembly of the catalytically proficient RNAP ...
The cells transiently transfected with Halo-tagged and non-tagged forms of IFNL3 or IFNL4 showed similar mRNA expression levels of the corresponding interferons (Figure 1A). Figure 1. Expression levels of IFNL3, IFNL4 and ISGs in transfected HuH7 cells. (A) Relative expression of tagged and ...
MCPIP1 (Regnase 1), a protein that dampens the inflammatory cascade, inhibits NF-κB activity and cleaves transcripts that encode pro-inflammatory cytokines.We evaluated MCPIP1 expression in the liver and peripheral blood mononuclear cells (PBMCs) of 36 control and NAFLD patients hospitalized for ...
(1997) GTP cyclohydrolase I feedback regulatory protein is a pentamer of identical subunits: purification, cDNA cloning, and bacterial expression. J. Biol. Chem. 272 , 9690–9696. PubMedYoneyama T, Brewer JM, and Hatakeyama K. GTP cyclo- hydrolase I feedback regulatory protein is a penta...
( 1993 ). Homomeric and native α7 acetylcholine receptors exhibit remarkably similar but non-identical pharmacological properties, suggesting that the native receptor is a heteromeric protein complex . FEBS Lett. 327 : 241 – 246 .Anand, R. , Peng, X. & Lindstrom, J. ( 1993 ). Homomeric ...
All sequenced genomes of representatives of the Francisella genus contain two rpoA genes, which encode non-identical RNA polymerase (RNAP) subunits, α1 and α2. In all other bacteria studied to date, a dimer of identical α subunits initiates the assembly of the catalytically proficient RNAP ...