From a mechanistic point of view, it is believed that the pharmacological manipulation of the gut ECS may be beneficial in attenuating intestinal chronic inflammation at three levels, namely by: (i) decreasing the release of neurotransmitters that control intestinal motility and secretion; (ii) reduc...
Effects on Tracheal Cells and Bronchial Mucus Secretion Chapter © 2016 References Sirois, P., andP. Borgeat. 1982. Mediators of immediate hypersensitivity.In Immunopharmacology. P. Sirois, M. Rola-Pleszczynski, editors. Elsevier/North-Holland, Amsterdam. 201–202. Google Scholar Wasserman, ...
HOs exhibit vast biological activities including the stimulation of insulin secretion by glucose induction, an increase of intracellular calcium levels in pancreatic islets cells, and the induction of hyperpolarization of the membrane potential in neurons [115]. 15-LOX is subdivided into two isoforms, ...
12-HETENeutrophil chemotaxis, stimulates glucose-induced insulin secretion 15-HETEInhibits 5- and 12-lipoxygenase Lipoxin ASuperoxide anion generation, chemotaxis Lipoxin BInhibits NK-cell activity Eicosapentaenoic acid PGE3Mild antiaggregatory, vasodilation ...
Important to clinical research, they are notably involved in the regulation of inflammation, thrombosis, endothelial function, vascular tone and insulin secretion, each of these systems being either stimulated or inhibited by the different oxylipin types as simplified in Fig. 2. Many oxylipins exert ...
In pancreatic β-cells, iPLA2VIA overexpression enhances glucose-induced AA release and insulin secretion (Ma et al., 2001). Independent iPLA2IVA functions in the regulation of capacitive Ca+2 entries with calmodulin, which inhibits iPLA2IVA. Upon Ca+2 depletion, calmodulin dissociates from iPL...