Eicosanoids and their receptors constitute a complex network that the current knowledge demonstrates they are involved in intestinal epithelium maintenance and the control of barrier function and consequently in the gastrointestinal homeostasis as summarized Fig. 4. Despite significant advances in the diagnosi...
have not been characterized. Epoxyeicosatrienic acids, important regu-lators of renal and cardiovascular function, are synthesized in endothelial cells by thecytochrome P450enzymes. Isoecosanoids are unique in that they are produced by a nonenzymatic free radical–based attack on arachidonic acid. ...
The demonstration of a role for microsomal P450 in the metabolism of endogenous pools of established this enzyme system as a member of the cascade and characterized a new an important metabolic function for this enzyme system. Studies from several laboratories documenting the powerful biological ...
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Whole body plethysmographic analysis was performed to assay lung function. Results The lung Na/K-ATPase activity of mice was completely inhibited by an OA dose of 10 μmol, an effect also obtained with 10-3μmol of ouabain, as demonstrated by the decreased Rb+ incorporation in the lungs. ...
Effects of high dose aleglitazar on renal function in patients with type 2 diabetes. Int J Cardiol. 2011;151(2):136–42.Wilson MW, Lay LT, Chow CK, et al. Altered hepatic eicosanoid concentrations in rats treated with the peroxisome proliferators ciprofibrate and perfluorodecanoic acid. ...
Increased numbers of lipid bodies correlated quantitatively with the ‘priming’ response of eosinophils to form enhanced amounts of the 5–lipoxygenase–derived eicosanoid, LTC4. Conclusion: ld>Lipid bodies in eosinophils function as intracellular domains that are both depots of esterified arachidonate...
In excised barnacles, it also caused muscular contractions of the whole body mass. The breakdown products of BMSF, however, were without such activities. The function of BMSF in facilitating fertilisation in barnacles is comparable to the role of other eicosanoids in human reproduction, reinforcing...
Increased numbers of lipid bodies correlated quantitatively with the ‘priming’ response of eosinophils to form enhanced amounts of the 5–lipoxygenase–derived eicosanoid, LTC[sub 4] . Conclusion: Lipid bodies in eosinophils function as intracellular domains that are both depots of esterified ...
Our interests in lipid bodies relate to the roles that these structures play in arachidonate metabolism by eosinophils and other leukocytes involved in inflammation. Findings indicate that lipid bodies in these leukocytes can function as intracellular domains that are both depots of esterified arachidonate...