We focused on a Z-linked gene, 17 beta-hydroxysteroid dehydrogenase type IV (HSD17B4), coding for a steroidogenic enzyme that converts estradiol (E2) into an inactive metabolite. HSD17B4 mRNA is expressed more in the song regions of males compared to females throughout development, suggesting...
Separation of a 17 beta-hydroxysteroid dehydrogenase from the 3(17) beta-hydroxysteroid dehydrogenase and comparison of the two enzymes. When a crude extract of Pseudomonas testosteroni induced with testosterone was subjected to polyacrylamide gel electrophoresis, six bands that stained for 17β-...
The HSD17B4 gene codes for a 80 kDa multifunctional enzyme containing three distinct functional domains and is localized in peroxisomes. The N-terminal part exhibits 3-hydroxyacyl-CoA dehydrogenase and 17β-hydroxysteroid dehydrogenase activity whereas the central part shows enoyl-CoA hydratase activity....
Biology and clinical relevance of Hydroxysteroid (17beta) dehydrogenase enzymes Xue-YingHe, ...Song-YuYang, inMolecular and Cellular Endocrinology, 2019 5Concluding remarks 17β-Hydroxysteroid dehydrogenasesare indispensable neurosteroidogenic enzymes. The neurosteroids synthesized in neurons and glia, can ...
17beta-Hydroxysteroid dehydrogenase (17beta-HSD) from the filamentous fungus Cochliobolus lunatus (17beta-HSDcl) catalyses the reduction of steroids and of several o- and p-quinones. After purification of the enzyme, its partial amino acid sequence was determined. A PCR fragment amplified with pri...
Human 17 beta-hydroxysteroid dehydrogenase (17-HSD) type 1 catalyzes the conversion of the low activity estrogen, estrone, into highly active estradiol, bo... T Puranen,M Poutanen,D Ghosh,... - 《Molecular Endocrinology》 被引量: 118发表: 1997年 Structural and biochemical characterization of ...
The majority of human 17β-HSDs described belong to the short-chain dehydrogenase/reductase (SDR) superfamily, with the exception of 17β-HSD5. SDRs constitute a large protein family of oxidoreductases, present in all forms of life. Members of this family are mainly oligomeric enzymes, and typ...
内异症组类固醇类产生因子-1(steroidgenic factor-1,SF-1)、小鸡卵清蛋白上游启动转录因子(chicken ovalbumin upstream-transcription factor,COUP-TF),17-β-羟甾类脱氢酶1(17-beta-hydroxysteroid dehydrogenase 1,17-β-HSD 1)和17-β-羟甾类脱氢酶2(17-beta-hydroxysteroid dehydrogenase 2,17-β-HSD 2)...
The 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) activity in rat and mouse preimplantation embryos was determined by measuring the interconversion of... JT Wu,PS Matsumoto - 《Biology of Reproduction》 被引量: 28发表: 1985年 In vitro 17beta-hydroxysteroid dehydrogenase activity in human thymu...
3-hydroxysteroidaldo-keto reductasedehydrogenasesecosteroidsshort-chain dehydrogenases/reductasesThe patient was admitted to our hospital at 19 and again at 22-yr of age for hirsutism and hypertension. Her baseline and ACTH-stimulated plasma 17-hydroxy pregnenolone, dehydroepiandrosterone and dehydro...