In contrast, a novel loss-of-function mutation (rs72613567:TA) in the 17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) gene has been identified as a protective factor against MASLD, other chronic liver diseases, and HCC, especially in at-risk individuals.19,20This variant leads to a splice...
17beta-Hydroxysteroid dehydrogenase type 1 (17beta-HSD1) catalyzes the formation of the potent proliferation-stimulating hormone estradiol, and it is thus involved in the development of hormone-dependent breast cancer. Due to its high substrate specificity and the known relationshi...
Provided herein are non-steroidal 17beta-hydroxysteroid dehydrogenase type 1 and type 2 (17β-HSD1 and 17β-HSD2) inhibitors, their production and use, especially for the treatment and for prophylaxis of hormone-related diseases.Inventors: Hartmann, Rolf (Saarbruecken, DE) Frotscher, Martin (Su...
Monte Carlo-minimized energy profile of estradiol in the ligand-binding tunnel of 17 beta-hydro- xysteroid dehydrogenase: atomic mechanisms of steroid recognition. Proteins. 38:414-427.Zhorov BS, Lin SX (2000) Monte Carlo-minimized energy profile of estradiol in the ligand-binding tunnel ...