Summary鈥 We investigated the possibility that variations of the metabolism of xenobiotic compounds might be involved in the process of bladder carcinogenesis, by studying activation reactions (phase I) and detoxification reactions (phase II) of xenobiotic compounds in a group of patients with ...
Define hydroxylations. hydroxylations synonyms, hydroxylations pronunciation, hydroxylations translation, English dictionary definition of hydroxylations. tr.v. hy·drox·yl·at·ed , hy·drox·yl·at·ing , hy·drox·yl·ates To introduce hydroxyl into
The requirement for normal-phase HPLC in resolving the metabolites formed during lauric acid metabolism is demonstrated.Access through your organization Check access to the full text by signing in through your organization. Access through your organization ...
Inhibition of the microsomal metabolism of 1,8-cineole in the common brushtail possum (Trichosurus vulpecula) by terpenes and other chemicals 2. Ketoconazole inhibited the major reactions of terpene-induced microsomes in both species: 9-hydroxylation in the possum and 2-hydroxylation in the rat......
An investigation of steroid metabolism in a 28-year-old male with metastatic adrenocortical carcinoma, who exhibited feminization, hypertension, edema and acne, has yielded information on the role of steroids in the production of these signs and symptoms. Initially, when feminization was the only fin...
Following centrifugation, the organic phase was collected while the aqueous phase was submitted twice to the same extraction procedure with 15 ml ethyl ace- tate:methanol(9: 1, v:v). The combined organic phases were then evaporated under a stream of nitrogen. Separation of [3H]-D3 and L3H...
We further selected the two periovulatory samples (samples three and four of the six sequential follicular phase samples) on the basis that oestrogen levels would be at their peak in these samples and this would maximise any differences in levels between CYP3A7*1C carriers and non-carriers. To...
Adipocyte-derived factor as a modulator of oxidative estrogen metabolism: implications for obesity and estrogen-dependent breast cancer. (MEM) plusdipocyte-conditionededia (ACM) wastudied.he 1:1CM-MEMultureystemesulted inubstantialndighlyignificant decrease in 2-hydroxylationf estradiol... Bradlow...
1 7 Palovaara S, Tybring G, Laine K. The effect of ethinyloestradiol and levonorgestrel on CYP2C19-mediated metabolism of omeprazole in healthy female subjects. Br J Clin Pharmacol 2003; 56: 232–7. 1 8 Meng QH, Liu YS, Jing SM, Hu YZ. Study on the application of index of composite...
1, 1993. “Tumor-specific Expression of Cytochrome P450 CYP1B11” by Murray et al. pp. 3026-3031; Cancer Research—Jul. 15, 1997. “Reductive Metabolism: its Application in Prodrug Activation” by Patterson et al. (XP-002106818) pp. 72-79. ...