Drug Therapy Guidelines: Hyaluronan Injections for Musculoskeletal Conditions Hyalgan®, Supartz®, Orthovisc® or Euflexxa® (intra-articular injections of sodium hyaluronate) Synvisc® (hylan G-F 20)affects an estimated 20.7 million Americans, mostly after age 45, and occurs in women ...
The present study suggests that five weekly intra-articular injections of sodium hyaluronate are well tolerated, can provide sustained relief of pain, and can improve function in Asian patients with osteoarthritis of the knee. Level of Evidence Therapeutic study, Level I-1a (randomized controlled tria...
HYALGAN®is contraindicated in patients with known hypersensitivity to hyaluronate preparations. Intra-articular injections are contraindicated in cases of present infections or skin diseases in the area of the injection site to reduce the potential for developing septic arthritis. ...
Orthopecis A hyaluronate used to treat osteoarthritic knee pain in Pts unresponsive to conservative therapy or simple analgesics; it is injected directly into the knee; relief lasts up to 6 months. SeeOsteoarthritis. McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill ...
The efficacy of intra-articular Hyalgan® injections as a treatment for the pain of OA is likely due, in part, to the dramatic reduction of inflammatory macrophages via reduced proliferation and induced apoptosis, as presented in this study. Chronic inflammatory reactions, as in OA, are charact...
High molecular weight sodium hyaluronate (hyalectin) in osteoarthritis of the knee: a 1 year placebo-controlled trial. Osteoarthritis Cartilage 1993; 1: 97–103 Article PubMed CAS Google Scholar Scali JJ. Intra-articular hyaluronic acid in the treatment of osteoarthritis of the knee: a long ...
Long-term effect of sodium hyaluronate (Hyalgan®) on osteoarthritis progression in a rabbit model Background: Intra-articular (IA) hyaluronan (HA) injections are approved for the treatment of knee osteoarthritis (OA) pain. One of the currently available... D Amiel,T Toyoguchi,K Kobayashi,....
This randomized, double-blind, placebo-controlled studyevaluated the efficacy and tolerability of this preparation in a Taiwanese population.Methods: Two hundred patients with mild to moderate OA of the knee were randomized toreceive five weekly intra-articular injections of sodium hyaluronate or placebo...
MATERIALS AND METHODS: Thirty consecutive patients with ankle OA documented by X-ray were randomized to treatment with five weekly injections of either sodium hyaluronate 2 mL (HYL) or phosphate-buffered saline 2 mL (control) in the tibiotalar joint. The primary endpoint was pain on movement ...
In the first group, 0.5ml of vitreous body was autologously injected into the rabbit's knee. In the second group, homologous vitreous body from one rabbit was injected into the left knee of another rabbit. In the third group, 0.5ml of sodium hyaluronate (Hyalgan) was similarly injected ...