ResearchOpen Access11 Feb 2025Nature Communications Volume: 16, P: 1550 Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington’s disease decades before clinical motor diagnosis A comprehensive longitudinal analysis of individuals with preclinical Huntington’s dise...
Translational research in Huntington's disease: opening up for disease modifying treatment. Transl Neurodegener (2013) 2(1):2. doi:10.1186/2047-9158-2-2Burgunder JM (2013) Translational research in Huntington's disease: opening up for disease modifying treatment. Transl Neurodegener 2: 2....
: A controlled trial of fluoxetine in nondepressed patients with Huntington’s disease. Mov Disord 1997, 12: 397–401. Article PubMed CAS Google Scholar Isbister GK, Buckley NA: The pathophysiology of serotonin toxicity in animals and humans: implications for diagnosis and treatment. Clin ...
The UW team, lead by Dr. Thomas Moeller, research associate professor of neurology, had previously studied the role of inflammation and immune response in neurodegenerative diseases like Huntington's and ALS, also known as Lou Gehrig's disease. In this study, they found that patients with Huntin...
For the first time, scientists at the Stowers Institute for Medical Research have uncovered the structure of the first step inamyloidformation, called the nucleus, for Huntington's disease. The study published ineLifefrom the lab of Associate Investigator Randal Halfmann, Ph.D., proposes a new,...
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iPSCs and embryonic stem cells may be able to make large numbers of neural stem cells. People with the degenerative disorder Huntington’s disease could receive treatment with stem cells to slow development of symptoms. Mesenchymal stem cells (MSC) have been shown to have significant effects on ...
Prilenia is also testing pridopidine for amyotrophic lateral sclerosis, another neurodegenerative disease.Therapy snapshotTreatment name: Pridopidine Administration: Being tested in Huntington’s as an oral capsule Clinical testing: Completed a Phase 3 clinical trial that failed to meet its main goal...
Treatment and Medication Options for Huntington’s Disease There’s no cure for Huntington’s disease and no proven treatments that slow the progression of symptoms. However, there are some medications that can lessen the burden of some of the physical and mental symptoms of the condition. ...
The Huntington's Disease Collaborative Research Group (Mar. 26, 1993) “A novel gene containing a trinucleotide repeat that expanded and unstable on Huntington's disease chromosomes.” Cell 72(6): 971-83.* Ashizawa et al. (Jun. 1994) “CAG repeat size and clinical presentation in Huntington...