Adonay S. Nunes İlkay Yıldız Potter Ashkan Vaziri ResearchOpen Access25 Feb 2025Communications Medicine Volume: 5, P: 50 Accelerated epigenetic aging in Huntington’s disease involves polycomb repressive complex 1 Loss of epigenetic information is a hallmark of cellular aging. Here, authors...
Huntington's disease (HD) is an autosomal-dominant disorder caused by a pathological expansion of a trinucleotide repeat (CAG) on exon 1 of the huntingtin (HTT) gene. HD is characterized by the presence of chorea, alongside other hyperkinesia, parkinsonism and a combination of cognitive and ...
By analyzing human samples and multiple mouse models of Huntington’s disease, we found that complement proteins and microglia mediate early and selective loss of corticostriatal synapses. Strategies that block this process can reduce synaptic loss, increase excitatory input to the striatum and prevent ...
Currently, the ten qualifying conditions include cancer, HIV or AIDS, Parkinson's disease, Huntington's disease, ALS, multiple sclerosis, epilepsy, neuropathy, inflammatory bowel disease and some spinal cord injuries. Dec 1, 2016 CBS2 Exclusive: Tour One Of New York's Medical Marijuana Product...
The US Phase 1/2 clinical trial of AMT-130 for the treatment of Huntington’s disease is exploring the safety, tolerability, and efficacy signals in a planned 26 total patients with early manifest Huntington’s disease split into ...
A new UCLA Health study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease and triggering downstream ... Feb 11, 2025 ...
Coelho, MMestre, TFerreira, J J
A common heart drug may slow the progression of Huntington's disease (HD), according to a new study by University of Iowa Health Care researchers. Dec 2, 2024 0 141 Medications Patients may become unnecessarily depressed by common heart medicine, study finds ...
Huntington's disease (HD) is a devastating, autosomal-dominant inherited, neurodegenerative disorder characterized by progressive motor deficits, cognitive impairments, and neuropsychiatric symptoms. It is caused by excessive cytosine-adenine-guanine (CAG) trinucleotide repeats within the huntingtin gene (HTT...
Coelho, MMestre, TFerreira, J J