Fukushima, YoshimitsuIkeda, Shu‐ichiBlackwell Publishing AsiaGeriatrics & Gerontology InternationalYoshida K, Yanagawa S, Tsuchiya A, Nakajima T, Fukushima Y, Ikeda Si. Huntington's disease with onset ages greater than 60 years. Geriatr Gerontol Int. 2007;7(1): 80-2....
Huntington’s disease; CAG; HTT gene; intermediate allele; bipolar disorder; psychiatric disorder 1. Introduction Expansion of CAG triplets in the huntingtin gene (HTT) on chromosome 4 is responsible for Huntington’s disease (HD). The presence of 40 or more CAG triplets is invariably associated...
Huntington’s disease (HD) is a neurodegenerative disorder characterized by a triad of motor, cognitive, and psychiatric declines. The cause of HD is genetic, namely an autosomal-dominant expansion of the CAG polyglutamine repeat within the protein-coding region of the HTT (huntingtin) gene providi...
摘要: At the forefront of medicine, Gene Therapy brings you the latest research into genetic and cell-based technologies to treat disease. It also publishes Progress & Prospects reviews and News and Commentary articles, which highlight the cutting edge of the field....
Reynolds, G PDalton, C FReynolds G. P. and Dalton C. F. (1998) Transgenic models and subcellular pathology-- do they tell us what goes wrong in Hun- tington's disease? Mol. Psychiatry 3, 192-195.Reynolds, G. P., and Dalton, C. F. 1998. Transgenic models and subcellular ...
2016. GSK-3尾-in- duced Tau pathology drives hippocampal neuronal cell death in Huntington's disease: involvement of astrocyte-neuron interactions. Cell Death Dis 7: e2206.L'Episcopo F, Drouin-Ouellet J, Tirolo C, Pulvirenti A, Giugno R, Testa N, Caniglia S, Serapide MF, Cisbani G, ...
fullerenols; Drosophila melanogaster; Huntington’s disease; oxidative stress; neurodegeneration1. Introduction Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by the mutation in the huntingtin (Htt) gene which generates a mutant protein (HTT) with an expanded ...
Connor, B.; Sun, Y.; von Hieber, D.; Tang, S.K.; Jones, K.S.; Maucksch, C. AAV1/2-mediated BDNF gene therapy in a transgenic rat model of Huntington's disease. Gene Ther. 2016, 23, 283-295. [CrossRef] [PubMed]
that physical activity reduces the risk of coronary heart disease, stroke, type II diabetes mellitus, arterial hypertension, and osteoporosis [2] and might be beneficial in preventing and treating several neurodegenerative disorders such as Parkinson’s disease (PD) and Alzheimer’s disease [3,4]....
Huntington’s disease; Brodmann area 4; tissue-specific network analysis; variant effect; function interaction network 1. Introduction Huntington’s disease (HD) is a trinucleotide repeat disorder caused by a CAG repeat expansion affecting the medium spiny neurons in the brain [1,2,3,4]. CAG ...