Salman, M.; Sharma, P.; Alam, I.; Tabassum, H.; Parvez, S. Naringenin mitigates behavioral alterations and provides neuroprotection against 3-nitropropinoic acid-induced Huntington’s disease like symptoms in rats.Nutr. Neurosci.2022,25, 1898–1908. [Google Scholar] [CrossRef] ...
The onset of HD is conventionally defined by the onset of motor symptoms, but psychiatric disturbances can precede the motor phase by up to twenty years. The aims of the present study are to identify HD patients in the pre-motor phase of the disease among patients diagnosed with bipolar ...
Disease severity was assessed using the Total Functional Capacity (TFC) [15], with higher scores indicating more intact functioning. The severity of psychiatric symptoms was assessed using the Problem Behaviours Assessment (PBA), with higher scores indicating greater severity [17]. Cognition was ...
Huntington’s disease (HD) is a progressive neurodegenerative disorder caused due to a CAG repeat expansion in the huntingtin (HTT) gene. The primary symptoms of HD include motor dysfunction such as chorea, dystonia, and involuntary movements. The primary motor cortex (BA4) is the key brain re...
, especially microgliosis. Altogether, our results indicate that RTP801 could be a marker of hippocampal neuroinflammation in HD patients and a promising therapeutic target of the disease. Keywords: RTP801/REDD1;Huntington’s disease;neuroinflammation;hippocampus;cognitive dysfunction...
The brain-derived neurotrophic factor (BDNF) is implicated in the function and survival of striatal neurons. Deficits in neurotrophic support by BDNF have been hypothesized to contribute to the neurodegeneration of striatal neurons in Huntington’s disease (HD). This article outlines an investigation ...