(2002) Targeted beta-globin gene conversion in human hematopoietic CD34(+) and Lin(-)CD38(-)cells. Gene Ther., 9, 118-126.LIU H, AGARWAL S, KMIEC E, DAVIS BR. Targeted beta- globin gene conversion in human hema
SANDERS-HAIGH L, ANDERSON WF, FRANCKE U: The P-globin gene is on the short arm of human chromosome 11. Nature 283:683-686, 1980Sanders-Haigh L, Anderson WF, Franke U: The p-globin gene is on the short arm of human chromosome 11. Nature 283:683,1980...
We have shown that the minimal enhancer fragment present in the 3'-flanking region of the human beta-globin gene contains four regions that bind nuclear proteins in vitro. By using gel mobility shift and DNase I footprinting assays, we were able to show that each of these regions binds an ...
The beta-globin gene is on the short arm of human chromosome 11. Investigations on the regulation of human globin gene expression are assisted by a knowledge of the chromosomal location of the globin genes. Previous studies 1 have mapped the α-globin locus to human chromosome (HC) 16 and ...
The human beta-globin locus is a highly complex genetic system that has become a classical model for studying the regulation of eukaryotic gene expression. The locus consists of five functional beta-like globin genes, epsilon- Ggamma-Agamma-delta-beta and a powerful upstream regulatory element, ...
Here we show using RNA FISH that in erythroid cells, intergenic transcription in the human β-globin locus occurs over a region of greater than 250 kb including several genes in the nearby olfactory receptor gene cluster. This entire region is transcribed during S phase of the cell cycle. ...
Thermal denaturation and cesium chloride density gradient centrifugation of DNA-cDNA hybrids can therefore provide accurate information on the base composition of mRNA related sequences of any single copy gene for which a relatively pure cDNA can be obtained, without the necessity for direct nucleotide...
The human beta-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers. EMBO J. 7:377-384.Antoniou, M., E. deBoer, G. Habets, and F. Grosveld. 1988. The human 3-globin gene contains multiple regulatory regions: iden- tification of one...
Characterization of the DNase I hypersensitive site 3'of the human β globin gene domain. Blood 1993; 81:2781-90.Fleenor DE,Kaufman RE.Characterization of the DNase I hypersensitive site 3’ of the human beta globin gene domain. Blood . 1993...
The human beta-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers. EMBO J. 1988; 7 :377–384.Antoniou, M.. deBoer, E., Habets. G. and Grosveld. F. (1988) The human beta-globin gene contains multiple regulatory regions: ...