a systematic research work of an application of the hSDNSF in various signal pathways and transcription factor regulation networks of human embryonic stem cells is performed, and the obtained results show that the hSDNSF and the FGF2 have the similar stem cell self-renewal promotion mechanism; de...
application of mouse embryonic stem cells has been in studies of gene function throughhomologous recombination. These studies were made possible by the remarkable ability of genetically-modified embryonic stem cells to incorporate into all tissues of a developing mouse after injection into ablastocyst, ...
Our chemical approach provides a platform for the generation and application of human pluripotent stem cells in biomedicine. This study lays foundations for developing regenerative therapeutic strategies that use well-defined chemicals to change cell fates in humans. This is a preview of subscription ...
Given the above historical and developmental overview (Fig.1), the germline stem cell (GSC) is a unique cell type that produces more stem cells via self-renewal or different states/subtypes of stem cells during germline development, and finally differentiate into specialized cells, spermatozoa and ...
Human urine-derived stem cells (USCs) have great application potential for cytotherapy as they can be obtained by non-invasive and simple methods. Silicate bioceramics, including calcium silicate (CS), can stimulate osteogenic differentiation of stem cells. However, the effects of silicate bioceramics...
The development of any stem-cell-based therapy (and a potential one for deafness is no exception) relies on the generation of the necessary tools: 'cell drugs' that can be safely manufactured for their clinical application. An increasing body of work has focussed on the identification, in anim...
The experiments include the studies of the proliferation and differentiation of stem cells, the differentiation of germ cells, and the impact on bone cells of a microgravity environment, said Li Xuzhi, deputy chief designer of the space application system of China's manned space program. ...
Induced pluripotent stem cells (iPSCs) are an essentially infinite source of stem cells owing to their self-renewal ability. Since the first report of these cells in 2006, human iPSCs have been derived from many cell types, including blood cells [29,30,31,32]. The original protocol, which...
Primary cardiac cells are difficult to access and maintain in cell culture for extensive experiments; therefore, the human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) became an excellent alternative. This technology enables a production of high number of patient- and disease-...
Over the years, adipose-derived mesenchymal stem cells have been extensively employed in regenerative medicine as an optimal cell therapy source for fostering skin ulcer healing. They have also demonstrated the capacity to enhance nerve regen...