Adoptive transfer of regulatory T cells (Treg) can prevent GVHD in rodents, indicating the therapeutic potential of Treg for GVHD in humans. However, the clinical application of Treg-based therapy is hampered by the low frequency of human Treg and the lack of a reliable model to test their ...
The heterogeneous phenotype, resistance to regulation and impaired regulatory function of CD8(+) T cells - especially at the target organ - might contribute to the persistence of autoimmune inflammation. Moreover, newly identified populations of tissue-resident CD8(+) T cells and their interaction ...
Inhibition of Notch using γ-secretase inhibitors or soluble Delta-like4-Fc during activation reduced expansion of antigen-specific CD8+ T cells, which was mirrored by decreased frequencies of interferon (IFN)γ-, tumor necrosis factor-α–, and granzymeB-producing CD8+ T cells. Moreover, T ...
Tumor-infiltrating macrophages and dendritic cells also express TIM-3. LAG3 is primarily expressed by activated CD4+ T cells, CD8+ T cells, FoxP3+ T regulatory cells (Tregs), and natural killer (NK) cells. Co-expression of multiple immune checkpoints help characterize the extent to which a...
Human CD8+ T Cells in Asthma: Possible Pathways and Roles for NK-Like Subtypes Nevertheless, one may conceptualize three principal roles for human NK-like CD8+ T cells in asthma: disease-promoting, regulatory, and/or tissue repair. ... L Olga,FA Mafalda,TB Luis - 《Frontiers in Immunology...
Metabolic reprogramming of human CD8(+) memory T cells through loss of SIRT1 Fei et al., "Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1," The Journal of Experimental Medicine, vol. 215, no. 1, ... Tsou,Chia-Lin,Johnson,... 被引量: 0发表: 0年 ...
科研人员利用小鼠模型研究了自然副流感病毒传播,量化了呼吸道内的记忆CD8 T细胞在不依赖病毒特异性抗体的情况下,减少感染易感性和传播范围的程度。研究结果表明,呼吸道内的组织驻留性CD8 T细胞需要抗病毒细胞因子IFN-γ,并导致呼吸道上皮细胞的转录程序发生变化。这些结果表明,呼吸道内的组织驻留性CD8 T细胞在保护宿主...
5b). We performed RNA-seq across CD8+ T cells from five donors to gain an unbiased view of the transcriptomic changes induced by BATF3 OE. Compared to control cells, there were over 1,100 DEGs distributed almost equally between upregulated and downregulated genes (Fig. 3c). Gene Ontology ...
Regulatory T cells (Tregs) are vital in maintaining self-tolerance and immune cell homeostasis. Tregs regulate the immune responses responsible for autoimmune diseases and suppress other cell responses. With this simple three-step magnetic isolation procedure ...
Start with mononuclear cells (MNCs)/peripheral blood mononuclear cells (PBMCs) from either whole blood or buffy coat, or T cell subsets including CD3+ T cells, CD4+ or CD8+ T cells, or regulatory T cells. Downstream applications The activated T cells can be analyzed shortly after activation...