Understanding human organ formation is a scientific challenge with far-reaching medical implications1,2. Three-dimensional stem-cell cultures have provided insights into human cell differentiation3,4. However,
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The high expression of CD147 protein, but not ACE2 protein, on erythrocytes and platelets, may also contribute to a "catch and clump” mechanism that increases the risk of thrombosis in various organ systems during SARS-CoV-2 infection [16]. Next, CD147 has been shown to serve as the ...
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Then, to gain insight into the specific networks affected by SMF exposure, which were not obvious by simple inspection of the genes involved, the microarray data was subject to software analysis and signaling networks consistent with tissue- or organ-level responses to magnetic exposure (that ...
Tables (1) Table Extras (2) Download all Table S1. Detailed steps for cell-type harmonization and integration using the CellHint algorithm, related to Figure 1 Table S2. List of organs and datasets used for constructing the multi-organ single-cell resource, related to Figure 7Volume...
B The diagram of the organ of Corti. C Representa- tive confocal microscopy images of GJB2 and GJB6 immunofluo- rescence in the apical, middle, and basal turns of the cochleae from wild-type and Gjb235delG/35delG mice at P14. The inner sulcus areas were shown. Three independent...
In the mutant clone (−/−, nonblue), the number of cells per sensory organ is reduced to two and does not contain a differentiated neuron. (B) Pedigree of the family of patient 6 (red arrow) with a severe microcephaly phenotype. Both affected individuals inherited variants from both ...
Epithelial regeneration is essential for barrier maintenance and organ function [36, 37]. Therefore, specific markers of intestinal stem cells (ISCs) were investigated. As depicted in Fig. 11E, CRS led to significantly decreased mRNA expression of ISCs, while Ri. intervention resulted in a pronounc...
(labeled as Main MuSC) and a transient differentiating state (labeled as MYOG+MuSC), we found two other lesser-known subtypes: TNFRSF12A+(TNF+) and ICAM1+(ICA+) MuSCs (Fig.2aand Supplementary Table2). Of note, it is possible that MYOG+MuSCs represent a potential artifact generated ...