Natural killer (NK) cells represent the primary innate immune cell type. They recognize and kill cancer by detecting downregulation of MHC class I on tumor cells and/or by detecting upregulation of ligands on tumor cells that bind to activating receptors on NK cells. NK cells are commonly iden...
Characterize Human Immune Cells by Flow Cytometry The immune system protects the host through a coordinated response of innate and adaptive immune cells. Defining each of these subsets can be a daunting task. Bio-Techne is here to help you visualize human immune cell subsets of interest with our...
Human peripheral blood contains two primary NK cell subsets (aside from uncommitted CD34+precursors found at low frequency): CD56brightand CD56dim. Each represents a distinct phenotypic and functional subset, with a well-described pattern of expression of cell surface and intracellular molecules as wel...
This GitHub repository for the Human Commons Cell Atlas contains uniformly preprocessed and filtered count matrices and cell type assignments that span 29 Human organs as well as marker gene lists for 31 Human organs. The count matrices are in thedatafolder and the marker gene lists in themarker...
Mature natural killer (NK) cells use Ca2+-dependent granule exocytosis and release of cytotoxic proteins, Fas ligand (FasL), and membrane-bound or secreted cytokines (tumor necrosis factor [TNF]-α) to induce target cell death. Fas belongs to the TNF receptor family of molecules, containing a...
P. et al. NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control. Cell 172, 1022–1037 (2018). Article CAS PubMed PubMed Central Google Scholar Theisen, D. & Murphy, K. The role of cDC1s in vivo: CD8 T cell priming through cross-...
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Thus, CD117 represented a useful bridging marker for the putative NK cell developmental pathway stemming from CD34+ progenitors in the tonsil. Excluding NK cells from the analyses (Figure 2A, right plot, blue brackets), we next observed that CD34+ cells and ILC2s were also mutually exclusive,...
CD335 NKp46/NCR1 Ly94, MAR-1, NCR1 9437 Clone 195314 CD336 NKp44/NCR2 LY95, NCR2 9436 CD337 NKp30/NCR3 NCR3 259197 Clone 210845 CD338 ABCG2 ABCP, BCRP, MXR 9429 CD339 Jagged 1 JAG1 182 CD340 ErbB2/Her2 HER2, Neu Oncogene, NGL, TKR1 2064 CD344 Frizzled-4 Frizzled...