Induced pluripotent stem cells (iPSCs) are generated via the expression of the transcription factors OCT4 (also known as POU5F1), SOX2, KLF4 and cMYC (OSKM) in somatic cells. In contrast to murine naive iPSCs, conventional human iPSCs are in a more devel
Naive pluripotent stem cellsEpiblast stemcellsX chromosome inactivationHuman embryonicstem cellsNormal mouse pluripotent stem cells were originallyderived from the inner cell mass (ICM) of blastocystsand shown to be the in vitro equivalent of those preimplantationembryonic cells, and thus were calledembryon...
Human naïve pluripotent stem cells (hnPSCs) can generate integrated models of blastocysts termed blastoids upon switch to inductive medium. However, the underlying mechanisms remain obscure. Here we report that self-renewing hnPSCs spontaneously and efficiently give rise to blastoids upon three ...
此外,转录组和全局 DNA 甲基化分析还显示,原代 hCiPS 细胞与植入前阶段的上胚层细胞和人类naive PS 细胞相似,但不同于primed PS 细胞(扩展数据图 9d-f),表明 hCiPS 细胞在被维持为稳定的 hCiPS 细胞系之前转变为naive的多能性状态。 我们发现,在将原代菌落直接转移到先前报道的naive PS 细胞培养条件 36,37...
北大邓宏魁团队2022年发布在NATURE上的文章:Chemical reprogramming of human somatic cells to pluripotent stem cells | Nature 以下为全文翻译(水平有限,仅供参考): 摘要: 细胞重编程可以控制细胞的特性以产生所需的细胞类型1-3。使用细胞固有成分,包括卵子细胞质和转录因子,可以强制体细胞重编程为多能干细胞4-7。
Pluripotent Stem Cells Species Human Application Genome Editing Area of Interest Stem Cell Biology Data Figures Figure 1.Human Pluripotent Stem Cell Naïve State qPCR Array Plate Configuration This illustration shows a quadrant of 96 unique primer-probe assays available on a 384-well qPCR plate (A...
Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development | Physiological Reviews 以下为全文翻译(水平有限,仅供参考): 摘要: 体细胞核移植的发现证明,体细胞可以携带与受精卵相同的遗传密码,激活该密码的部分足以将细胞重新编程到早期发育状态。近半个世纪后,诱导多能干细胞 (iPSC...
Human Pluripotent Stem Cell Cryopreservation Medium人多能干细胞冻存液 价格￥1740 起批量≥1瓶 最小起订1瓶 供货总量80瓶 发货地址广东省深圳市 建议售价￥电议 更新日期2025年02月25日 产品规格50 ml 即时洽谈立即询价查看联系方式 收藏产品发送留言 ...
HUMAN stem cellsEPITHELIAL cellsCHROMATOPHORESCELL morphologyPurpose Defined differentiation of functional RPE cells from human embryonic (hESC) or induced pluripotent stem cells (iPSC) is a prerequisite for their use in individualised disease modelling, drug discovery and transplantation for retinal diseases...
Cancer-Related Mutations Are Not Enriched in Naive Human Pluripotent Stem Cells Cell Stem Cell, Volume 28, Issue 1, 2021, pp. 164-169.e2 Giuliano Giuseppe Stirparo,…, Ge Guo View PDF Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening Cell Repor...