HLA-II peptides derived from the SARS-CoV-2 spike glycoprotein were aligned to the ECD sequence and a peptide density map was generated to help visualize the breadth and depth of sequence coverage. A schematic listing of the various subunits of the spike glycoprotein ECD and the results obtaine...
10.1038/srep38426 6 www.nature.com/scientificreports/ ('CavAb') is to both Na+ taanrdgeCtead2+bcyheaunknaerlyaontitcagCoanVisatns t(aFgiogn. 4isBts)3,5s.iOmuilrarfitnodfiunlgl-tlhenatgCthaT2+PuCpst1a7,kseubgygethstes DI pore is sensitive that essential phar- macological features ar...
As a part of its life cycle, C. albi- cans exists in a nonpathogenic yeast form as well as a potential pathogen during the hyphal stage. Recognized as a common component of the digestive and genital floras, C. albicans has the potential to cause superficial as well as disseminated ...
Melo Ferreira R, Sabo AR, Winfree S, Collins KS, Janosevic D, Gulbronson CJ, Cheng YH, Casbon L, Barwinska D, Ferkowicz MJ, et al. Integration of spatial and single-cell transcriptomics localizes epithelial cell-immune cross-talk in kidney injury. JCI Insight. 2021;22:e147703. Article...
All clinical symptoms of malaria are attributed to the blood stage of the parasite's life cycle where P. falciparum invades and multiplies within host red blood cells (RBCs). Resistance to the current state-of-the-art anti-malarial drug artemi...
Our kSOH → SO2H value of 1.1 × 103 m−1 s−1, for Prx2-C2S at a suboptimal pH, is comparable with 1.2 × 104 m−1 s−1 for the WT enzyme. Moreover, our chemical quench and time-resolved MS data (FIGURE 2, FIGURE 3) directly illustrate the rapid formation of the ...
Although TGF-β1 triggers primary early responses (e.g. Smad activation) and EMT in human HPC (HepG2) cells, cell cycle arrest and apoptosis are generally not promoted by TGF-β1 [21, 22]. Furthermore, TGF-β1 is known to be crucial for development of Langerhans cells, the cutaneous...
The placenta, known as the tree of life, takes root in the fertile soil of the mother’s uterus, nourishing the growth of new life. The remarkable organ undergoes highly dynamic changes, coordinating with the mother to meet the evolving demands of fetal development during pregnancy. The continu...
A clear division regarding AI’s positive impact on life and moral standing (Rainie et al., 2021). It is evident from the literature on the ethics of AI that besides its enormous advantages, many challenges also emerge with the development of AI in the context of moral values, behavior, ...
Furthermore, mtDNA data showed that intermarriages between the first settlers with Evenks women led to the establishment of genetic characteristics during the 15th century that are still observed today.Background The Yakuts (or Sakhas) from the Republic of Sakha are of particular interest because ...