Timeline of major advancements in stem cell technologies for the modelling of human brain tumors. The isolation and characterization of human neural stem cells (blue) together with pluripotent stem cell models (green) has paved the way for the modelling of human brain tumors (red) using these me...
The timeline is divided into intervals of 10 years, with events in each decade marked with the same background box. The time of the first establishment of various cell lines is marked above the timeline, while the time of the first use of these cell lines in trophoblast fusion models is m...
In order to focus on cell types rather than cell states, we first unified clusters of vRGs belonging to different stages of the cell cycle into a “cycling vRG” metacluster (Fig. 5a). Although all clusters had DEGs, we identified a higher number of DEGs in the cycling vRGs compared ...
The timeline of the experiment is depicted on the left. The red signal is the EGFR FISH probe. f, The NB cell line TR14 shifted the copy number distribution of MYCN ecDNA when treated with 43 nM vincristine for 12 weeks. g, The NB cell line CHP212 shifted the copy number ...
The transplantation of exosomes derived from human adipose-derived mesenchymal stem cells (hADSCs) has emerged as a prospective cellular-free therapeutic intervention for the treatment of neurodevelopmental disorders (NDDs), as well as autism spectrum di
protein, membrane protein, and nucleocapsid protein, which are critical for viral life cycle. The 5′-terminal region (two-thirds) is the non-structural protein coding region, comprising significant genes, which are essential for viral replication [48,49]. Genomic knowledge of hCoVs promotes the...
Secondly, a in vivo real-time monitoring method for heart function should be added to future evaluations to provide a whole course tracing, which may provide a clear timeline of the hUC-MSCs sheet working cycle after cell sheet transplantation. Thirdly, there are inter sample differences exist ...
Abnormalities of ventricular action potential cause malignant cardiac arrhythmias and sudden cardiac death. Here, we aim to identify microRNAs that regulate the human cardiac action potential and ask whether their manipulation allows for therapeutic modu
were consequently analyzed via an array of unbiased and high-throughput analytical approaches, including state-of-the-art TMT-16plex liquid chromatography/mass-spectrometry (LC/MS) proteomics, hybrid MS metabolomics, and flow cytometry panels to determine cell-cycle dynamics and rates of cell death....
The historical timeline on milestones in RBPs related to alternative splicing. The study of AS and AS-related RBPs can be traced back to the 1970s. In 1977, the interaction between RBPs and mRNA was first reported. The following year, the mechanism of AS was proposed, which marked the ...