Herein, we propose MIXTURE (huMan-In-the-loop eXplainable artificial intelligence Through the Use of REcurrent training), an original method to develop deep learning models for extracting pathologically significant findings based on an expert pathologist’s perspective with a small annotation effort. The...
With human-in-the-loop models, we can not only orchestrate and monitor the interactions among systems, but also to more effectively realize complex sociotechnical goals based on collective social behavior and norms. In other words, we can adapt larger initiatives to better fit local communities ...
Here, we present a precise graph-based AAM model, namedLocalMapper, via human-in-the-loop machine learning. Apart from previous ML-based approaches, which learn the AAM without correct answers, we manually label the AAM of reaction data to train the model. While the manual labeling of a la...
Oxidation Resistance 1 (OXR1) gene is a highly conserved gene of the TLDc domain-containing family. OXR1 is involved in fundamental biological and cellular processes, including DNA damage response, antioxidant pathways, cell cycle, neuronal protection, a
However, restricting the alignment to the 78 amino-acid region physically adjacent to the K+ selectivity filter (the pore loop from transmembrane region 5 to transmembrane region 6, which includes the K+ selectivity filter) rat and human KV2.1, they are identical and rat and human KV6.4 is ...
These results offer a first demonstration that techniques from algebraic topology offer a novel perspective on structural connectomics, highlighting loop-like paths as crucial features in the human brain’s structural architecture.Similar content being viewed by others Functional Geometry of Human ...
these connections are diagrammed in Figure 1; this figure shows both known connections between IL-6 and other molecular players (e.g., Ca2+ and TLR4) as well previously unappreciated links (e.g., ganglioside involvement in IL-6 activation that acts even in the absence of SMF, offering a ...
Sequence alignment algorithms such as BLAST and PSI-BLAST could not detect a homolog of these enzymes from the protein databank. SiaTs, thus, belong to the hard/medium target category in the CASP experiments. The objective of the current work is to model the 3-D structures of human SiaTs ...
Here, we measured the transcriptional activity of DNA sequences that represent an ~100 times larger sequence space than the human genome using massively parallel reporter assays (MPRAs). Machine learning models revealed that transcription factors (TFs) generally act in an additive manner with weak ...
Longitudinal sampling of the stool has yielded important insights into the ecological dynamics of the human gut microbiome. However, human stool samples are available approximately once per day, while commensal population doubling times are likely on the