Human Immune Cell Marker Guide T Cells CD3 + NK Cells CD56 + and CD3 – Cytotoxic Granzyme + or Perforin + PB Immature/ Regulatory NK Cells CD56 high and CD16 – and NCR + PB Cytotoxic NK Cells CD56 low and CD16 + CD69 + Activated Plasmacytoid Dendritic Cells (pDCs) Conventional Dendr...
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Human innate and adaptive immune cells from hNSG mice are functional and respond to cell-specific stimulation. (A) Human splenocytes upregulate cell surface expression of activation marker CD69 48 hours after stimulation with human CD3/28 antibody and rhIL2. (B) Proportion of hCD4+and hCD...
Cell conversion was monitored through fluorescence-activated-cell-sorting (FACS) analysis of the B cell marker CD19 and the macrophage marker Mac1 (also known as CD11b; encoded by the gene ITGAM; Fig. 5a,b and Extended Data Fig. 7d)40,41. As expected, C/EBPα expression led to a ...
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The host immune escape of hypoimmunogenic cells carries a risk of tumorigenicity and treatment-related toxicities. To mitigate this risk, the introduction of a safety switch has been considered. The herpes simplex virus thymidine kinase (HSV-TK) is utilized as a safety switch to control cell grow...
S2A–C). These cells could be assigned to 10 distinct cell types (Fig. 1B) using known marker genes: malignant cells (11,601 cells, 37.1%, marked with EPCAM, keratin 19 [KRT19], and KRT7); cholangiocytes (546 cells, 1.7%, marked with FYXD2, TM4SF4, and ANXA4); hepatocytes ...
The response to neoadjuvant chemotherapy in breast cancer patients is usually assessed by pCR and RCB score. However, the prognostic value of these parameters is still in discussion. We showed recently that an epirubicin/docetaxel therapy is associated with an increase in the cell death marker high...
Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression. Genome Biol. 20, 296 (2019). Article CAS PubMed PubMed Central Google Scholar Lu, Q. et al. Effect of penthorum chinense pursh compound on AFB1-induced immune imbalance via jak/...
Immune cell cytokine United States Patent 6537539 Abstract: Human Immune Cell Cytokine-like Hormone polypeptide and DNA (RNA) encoding such polypeptide in a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for ...