The generation of functional cardiomyocytes from human embryonic stem (hES) cells has several potential applications. Myocardial diseases resulting from damage of cardiac tissue affect millions of people, who may benefit from transplantation of cardiomyocytes. Such an application has already been ...
Here we show that transplantation of ∼750 million cryopreserved human embryonic stem cell–derived cardiomyocytes (hESC-CMs) enhances cardiac function in macaque monkeys with large myocardial infarctions. One month after hESC-CM transplantation, global left ventricular ejection fraction improved 10.6 ...
human embryonic stem cell technology: Large scale cell amplification and differentiation. Cytotechnology 2006; 50(1-3):181-190.Oh SK, Choo AB (2006) Human embryonic stem cell technology: large scale cell amplifi- cation and differentiation.Cytotechnology. 50:181-90....
In humans, SCNT was envisioned as a means of generating personalized embryonic stem cells from patients’ somatic cells, which could be used to study disease mechanisms and ultimately for cell-based therapies (Lanza et al., 1999; Yang et al., 2007). However, the derivation of human nuclear ...
Human embryonic stem (hES) cells are derived from theinner cell massof the 5-6 day embryonicblastocyst. These cells have the ability to self-renew and they are pluripotent, meaning that they have the ability to become any cell type in the primarygerm layers(ectoderm,mesoderm, or endoderm) ...
human neural precursor cell References Di Giorgio F, Boulting G, Bobrowicz S, Eggan K . Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation.Cell Stem Cell2008;3: 637–648. ...
Human embryonic stem cells (ESCs) maintain their pluripotency through a variety of molecular signaling pathways. Extracellular proteins like PDGF, Neurotrophins, FGF, BMPs, and WNT regulate signaling cascades leading to stem cell renewal or differentiation. For example, signaling through BMPs activates ...
Suggest new definitionWant to thank TFD for its existence? Tell a friend about us, add a link to this page, or visit the webmaster's page for free fun content. Link to this page: HESCR Facebook Twitter Feedback Complete English Grammar Rules is now available in paperback and eBook form...
In vivothe stem cell niche is an essential component in controlling and maintaining the stem cells ability to survive and respond to injury. Human embryonic stem cells (hESCs) appear to be an exception to this rule as they can be removed from their blastocytic microenvironment and maintained in...
Although cell-surface antigens of MSCs have been extensively explored, thereis no conclusive evidence that unique stem cells markers are associated with these adult cells. Therefore the aim of thisstudy was to examine expression of embryonic stem cell markers 展开 ...