In a collection of research articles and related content, the Human Cell Atlas consortium presents tools, data and ideas towards the generation of their first draft atlas of cells in the human body. 20 November
we explore five ways in which cell atlases, including the Human Cell Atlas, are already revealing valuable biological insights, and how they are poised to provide even greater benefits in the coming years. In particular, we discuss cell atlases as censuses of cells; as 3D maps of cells in ...
Census of Immune CellsBone marrowHomo sapiens10x378000Profiling of immunocytes by single cell RNA-seq for understanding human health and disease. Since the hdf5 files are derived from the cellranger pipeline, some information on their specific format can be foundhere ...
We employed this strategy to integrate cells from the five immune datasets, and based on this, revealed the expected transcriptomic organization of immune cells (Figures 5B and S6A). To benchmark CellHint against widely used data integration methods, we compared the performance of CellHint on ...
immunecells Fishembryo PathogenicTcells inMSmodel Musclecell differentiation CSCspectrum inglioma GSCBMP4 scRNA-Seq Insitu Thesequencer:amicroscopeforthe21 st century TheHumanCellAtlasProject What?Acensusofallcells •Types •States •Transitions •Location Why?Areferencemapforfunction •Foundational,...
Mapping these constellations of cells and discovering their function have been long-standing goals of scores of 21stcentury molecular cartographers working worldwide as part of theNational Institutes of Health’s “Brain Initiative Cell Census Network” project. The overarching purpose of t...
This new layer of information is setting the standard for how we define and study cells. For example, the CZ Biohub’s Tabula Sapiens is a human reference atlas that sampled multiple tissues from individual human donors and performed coordinated single-cell transcriptome analyses on live cells. ...
ABSTRACT:The Human Cell Atlas (HCA) Consortium was founded in 2016 as an open global initiative to map each cell type in the human body and create a three-dimensional (3-D) atlas. As of December 2024, 18 Biological Networks are assembling the first draft
tissue data (cells and nuclei are represented in rows, genes in columns).dNumber of detected genes per cell (top) and nucleus (bottom) across major cell types. Ch cholangiocytes, En endothelial cells, He hepatocytes, Im immune cells, Me mesenchymal cells. Boxplot shows the median (center ...
The Human BioMolecular Atlas Program (HuBMAP) aims to construct a 3D Human Reference Atlas (HRA) of the healthy adult body. Experts from 20+ consortia collaborate to develop a Common Coordinate Framework (CCF), knowledge graphs and tools that describe the multiscale structure of the human body ...