Using a consistent set of marker genes for immune cell annotation, we standardized the classification of immune cells and assessed their prevalence in both age groups. The integrated dataset revealed several co
6b,c). This integrated intestinal organoid atlas (HIOCA) covers epithelial states from the duodenum, ileum, colon and PSC-derived organoids, and contains a large fraction of mesenchymal cells, and minor populations of neural, endothelial and immune cell types (Fig. 3b,c and Extended Data Fig...
Purpose of reading this paper: This method is applicable in our group, also, the methods and definition for macrophages can help in my project. In-Depth Immunophenotyping of ccRCC Tumor Samples Using Mass Cytometry Immune Landscape in ccRCC T Cell Characterization Reveals Various Phenotypes Associated...
今天给同学们分享一篇实验文章“An integrated tumor, immune and microbiome atlas of colon cancer”,这篇文章发表在Nat Med期刊上,影响因子为82.9。 结果解读: AC-ICAM 概述 新鲜冷冻的肿瘤样本和配对的健康结肠组织(肿瘤-正常对)来自未接受全身治疗的具有结肠癌组织学诊断的患者,通过正交基因组平台进行了分析。在...
//doi.org/10.1038/s41514-024-00185-x An integrated single-cell atlas of blood immune cells in aging Igor Filippov 1,2 , Leif Schauser1 & Pärt Peterson 2 Check for updates Recent advances in single-cell technologies have facilitated studies on age-related alterations in the immune system....
To test for functionality, the B cell attempts to pair the µ chain with a surrogate light chain and express the product on the cell membrane. It is not known how the B cell confirms that these two proteins are successfully displayed. However, if the criteria for success are met, the ...
With INSIHGT, we map undescribed podocyte-to-parietal epithelial cell microfilaments in mouse glomeruli and neurofilament-intensive inclusion bodies in the human cerebellum, and identify NPY-proximal cell types defined by spatial morpho-proteomics in mouse hypothalamus. We anticipate that INSIHGT can ...
4 By contrast, left-sided tumors had more predominant suppression of MS4A1 (CD20 tumor-infiltrating B cell marker) and BACH2 (transcriptional regulator of B and T follicular helper cells), and a potential connection with calcium homeostasis may contribute to less immune infiltration and may ...
While the role of coding genes in immune cell function has been well characterized, the role of lncRNAs in these processes is just beginning to emerge [25] (Fig. 1). Here, we use the biological model system of macrophage activation as a framework to demonstrate how we approach the study ...
Comparison of the transcriptomes of specific human immune cell subsets As seen in our previous meta-analysis of mouse microarray data, the different leukocyte lineages can be defined by sets of coregulated genes. The largest leukocyte-enriched cluster is Cluster 2, a set of genes almost exclusively...