Expression levelMolecular farmingThe human CD14, a high affinity receptor for lipopolysaccharides (LPS), is involved in the innate immunity system and the inflammatory response. There is increasing interest in using recombinant approaches to produce purified CD14 protein for therapeutic uses. Plants ...
Consequently, we investigated calcitriol modulation of the expression of macrophage inhibitory factor (MIF) and macrophage surface specific protein CD14 , two key factors in regulating macrophage function and survival, in differentiated human adipocytes. Calcitriol markedly increased MIF and CD 14 expression...
The soluble LPS-binding protein (LBP) extracts monomeric LPS from the microbial membrane and transfers it to CD14 (cluster of differentiation 14). This membrane-bound protein then interacts with MD-2 (myeloid differentiation factor 2), constitutively associated with the TLR4 ectodomain. The ligand-...
CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a high affinity receptor for complexes of LPS and LPS binding protein (LBP). Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an...
PE anti-human CD14 Isotype : Mouse IgG1, κ Other Names : Monocyte differentiation antigen CD14, myeloid cell-specific leucine-rich glycoprotein, LPS receptor Size : 100 tests Price (USD) : 250 USD Reactivity : Human Clonality : Monoclonal ...
The effect of MCP-1 on the expression of MCP-1, CCR2, transforming growth factor-beta1 (TGF-beta1), and type I collagen in circulating human CD14-positive Mo was investigated. In addition, the impact of MCP-1-specific or TGF-beta1-specific antisense (AS) phosphorothioate ...
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2a), and the protein expression of ACOD1 was nearly blank in sgACOD1−2 and sgACOD1−3 tMACs (Fig. 2b). To reveal the function of ACOD1 in pro-inflammatory activation of macrophages, we found CD80 expression was higher in ACOD1-deleted tMACs after stimulation and the magnitude ...
TLR4, MD2 and CD14 protein expression (Fig. 2C). All these data show that LPS-primed human DCs adopt an anti-inflammatory phenotype characterized by an increased expression in immuno-regulatory mediators such as IDO1, IDO2, AhR and IL-10, as well as the inhibitory molecules PD-L1 and PD...
et al. Human dendritic cell subset 4 (DC4) correlates to a subset of CD14dim/–CD16++ monocytes. J. Allergy Clin. Immunol. 141, 2276–2279 (2018). Article PubMed Google Scholar Collin, M. & Bigley, V. Human dendritic cell subsets: an update. Immunology 154, 3–20 (2018). ...