brain and sensory, cognitive, and motor functions, a fact that was recognized long ago. The technique that has so far contributed most to functional brain mapping ispositronemission tomography (PET), which depends on the administration of radioactive-labeled substrates (for a review, seeChadwick ...
While single-cell technologies have greatly advanced our comprehension of human brain cell types and functions, studies including large numbers of donors and multiple brain regions are needed to extend our understanding of brain cell heterogeneity. Integrating atlas-level single-cell data presents a chan...
Here, we characterized a novel and deleteriousOXR1mutation in patients with severe neurological features. We produced patient-derived lymphoblasts, fibroblasts, iPSCs, and used the latter to generate monolayer neuronal cell cultures and various brain organoid models (e.g., hippocampus, hypothalamus, m...
21). For lncRNA homologs with similar functions, the order and the sequence of these functional elements may appear conserved under selection pressure, whereas other nonessential sequences may evolve rapidly. It should thus be possible to identify functionally conserved lncRNAs across species by ...
Microglia, the brain’s resident immune cells, play vital roles in brain development, and disorders like Alzheimer’s disease (AD). Human iPSC-derived microglia (iMG) provide a promising model to study these processes. However, existing iMG generation pr
Recent evidence supports the importance of the gut microbiota (GM) in the modulation of multiple functions associated with depression through the gut-brain axis (GBA). However, the underlying mechanisms remain poorly understood. Therefore, in the current study, we aimed to screen the microbiota out...
Human activity recognition (HAR) has multifaceted applications due to its worldly usage of acquisition devices such as smartphones, video cameras, and its
Using the ORF information, the transcripts are then labeled with attributes based on the protein hit. TAMA degradation signature The TAMA Degradation Signature (DegSig) score is intended to provide a metric for the relative amount of sequencing reads originating from degraded RNA. The DegSig score...
Astrocytes derived from adult human gingiva stem cells were passaged, split, and either plated in a planar collagen matrix or used for TE-RMS fabrication. Cell nuclei were labeled with Hoechst stain, and cells were immunostained for GFAP, Ezrin, and Robo2. Representative wide views of merged ...
Neurocognitive functions associated with microbiota The current findings suggest an involvement of brain networks involved in emotion-related cognition and executive functioning. The association between the gut microbiota and emotion-related functioning is a recurring topic in gut-brain research. Several of ...