Using both computational and experimental tools, we systematically investigated the dimerization process of the transmembrane domain (TMD) of IRE1α and found that, with help of the serine 450 residue, the conserved tryptophan 457 residue buttresses the core dimerization interface of IRE1α-TMD. BiFC...
This study examines the impact of artificial intelligence (AI) on loss in decision-making, laziness, and privacy concerns among university students in Pakistan and China. Like other sectors, education also adopts AI technologies to address modern-day cha
The transplantation of exosomes derived from human adipose-derived mesenchymal stem cells (hADSCs) has emerged as a prospective cellular-free therapeutic intervention for the treatment of neurodevelopmental disorders (NDDs), as well as autism spectrum di
Oncogene amplification on extrachromosomal DNA (ecDNA) is a common event, driving aggressive tumor growth, drug resistance and shorter survival. Currently, the impact of nonchromosomal oncogene inheritance—random identity by descent—is poorly understoo
The human brain is like a powerful computer that stores our memory and controls how we think and react. It has evolved over time and features some incredibly intricate parts that scientists still struggle to understand. The brain is the centre of the human nervous system, controlling our thought...
The microbe Akkermansia muciniphila was first isolated two decades ago1 and has emerged as an important member of the complex microbial community in the gastrointestinal tract.2 Over the last decad...
Some studies have suggested a possible associ- ation between physical activity and development of ALS but more work has to be done to confirm this hypoth- esis [27]. Additionally, head traumas, which persist as major health concern among football and other collision sports players, are being ...
These eHealth technologies, such as web-based interventions or mobile apps, are used to support health, well-being, and health care using technology [1]. Although the e in eHealth illustrates the importance of technology, eHealth encompasses much more than merely adding information and communication...
48 www.neuropsychopharmacology.org REVIEW Human and Rodent Homologies in Action Control: Corticostriatal Determinants of Goal-Directed and Habitual Action Bernard W Balleine*,1,2 and John P O'Doherty3,4 1Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia; 2...
Vol 437|1 September 2005|doi:10.1038/nature04072 ARTICLES Initial sequence of the chimpanzee genome and comparison with the human genome The Chimpanzee Sequencing and Analysis Consortium* Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the ...