alternative splicingelementary alternativeintronexonESTEDAS, an alternatively spliced human gene database, contains data on alignment of proteins, mRNAs, and ESTs. For 8324 human genes, the database contains information on all observed exons and introns and also elementary alternatives formed therefrom. ...
The historical timeline on milestones in RBPs related to alternative splicing. The study of AS and AS-related RBPs can be traced back to the 1970s. In 1977, the interaction between RBPs and mRNA was first reported. The following year, the mechanism of AS was proposed, which marked the o...
As is generally known, different isoforms of ITSN1 are highly regulated by alternative splicing [5]. Thus, we focused on identifying the specific splicing factor that regulates the alternative splicing of ITSN1. The splicing of exon 30 is critical for the formation of the two isoforms of ITSN1...
Alternative splicing (AS) represents a crucial method in mRNA level to regulate gene expression and contributes to the protein complexity. Abnormal splicing has been reported to play roles in several diseases, including cancers. We developed the OncoSplicing database for visualization of survival-associ...
Lareau LF, Green RE, Bhatnagar RS et al (2004) The evolving roles of alternative splicing. Curr Opin Struct Biol 14:273–282 Article PubMed CAS Google Scholar Lottin S, Adriaenssens E, Dupressoir T et al (2002) Overexpression of an ectopic H19 gene enhances the tumorigenic properties of...
Our data confirm the importance of alternative splicing in the cortex, dramatically increasing transcriptional diversity and representing an important mechanism underpinning gene regulation in the brain. We provide transcript-level data for human and mouse cortex as a resource to the scientific community....
18 heterozygous variations causing stop-gain mutation were identified from the GW14.5 specimen (Figure S3C), but none of them regulates the alternative splicing. CTCL knockdown in H9 cells RNA interference oligo against CTCL (5′-TGCTTGTTAACCTGGTCGA-3′) was cloned into lentivirus vector (pLenti...
Many other groups provided smaller numbers of database entries. We thank them all; a full list of the contributors of unpublished sequence is available as Supplementary Information. This work was supported in part by the National Human Genome Research Institute of the US NIH; The Wellcome Trust;...
To investigate how often outlier gene expression or alternative splicing occurred due to biological variation other than HPV integration, we permuted the sample identities of the HPV integration sites of each dataset multiple times. For TCGA data we permuted the sample data 100 times. For the 4 ...
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