2084 up-regulated genes and 2961 down-regulated genes were identified by differentially expressed gene (DEG) analysis. Then, gene ontology analysis was performed to explore the biological functions of DEGs, respectively. The up-regulated DEGs are mainly enriched in epidermal cell differentiation, ...
3+ WGCNA可替换PPI筛选hub基因 今天分享一篇文献《Identification of hub genes in colorectal cancer based on weighted gene co-expression network analysis and clinical data from The Cancer Genome Atlas》,来自Biosci Rep 2022年1月11日的文章,影响因子:3.840。Introduction 结直肠癌(CRC)包括结肠癌和直肠癌,是...
Song ZY, Chao F, Zhuo Z, Ma Z, Li W, Chen G. Identification of hub genes in prostate cancer using robust rank aggregation and weighted gene co-expression network analysis. Aging (Albany NY). 2019;11(13):4736-4756. Wang J, Chen L, Wang Y, Zhang J, Liang Y, Xu D (2013) A Co...
3+癌症hub基因分析 今天小编分享一篇2022年1月发表在PeerJ的文章(IF :3.061),题目为“Identification of key genes and biological pathways in Chinese lung cancer population using bioinformatics analysis”。 1 背景&方法 背景:识别准确的预后生物标志物对于改善肺癌患者的不良生存率...
To identify the hub genes that associated with chemo-radiotherapy sensitivity for cervical cancer and to explore the relationship between hub genes and var
Immune regulation is a pivotal factor in the pathogenesis and repair of spinal cord injury (SCI). This study aims to explore potential immune center genes associated with spinal cord injury. The public data set GSE151371 was obtained from the GEO databas
At the same time, the expression levels of sorafenib resistance-related DEGs were evaluated between normal sample tissues and liver cancer samples by using TCGA database. A Kaplan-Meier analysis was used to assess the prognostic value of sorafenib resistance-related genes in HCC. We also evaluated...
The pathogenic mechanisms of prostate cancer (PCa) remain to be defined. In this study, we utilized the Robust Rank Aggregation (RRA) method to integrate 10 eligible PCa microarray datasets from the GEO and identified a set of significant differentially expressed genes (DEGs) between tumor samples...
Colorectal cancer (CRC) is one of the most common tumors worldwide and is associated with high mortality. Here we performed bioinformatics analysis, which we validated using immunohistochemistry in order to search for hub genes that might serve as biomarkers or therapeutic targets in CRC. Based on...
Through this integrative analysis, we seek to uncover key hub genes involved in meniscal degeneration, which could serve as potential biomarkers or therapeutic targets for OA. Protein-protein interaction (PPI) network was constructed using Cytoscape software for further identification of the hub gene. ...