it may be a question of time before theHTTgene (along with other monogenic disorders) is included in such panels. This would pose new demands on the healthcare providers to manage patients with genetic test results acquired without any family history of HD17. ...
CAG repeats in the HTT gene within the non-pathological range influenced neuropsychological performances depending on global cognitive status. The logarithmic model suggested that the positive effect of CAG repeats in SCD patients decreases as the number of repeats grows.Bessi...
HTTHead Thrust Test(clinical test for vestibular organ dysfunction) HTTHarris Tag and Title(Stevensville, MD) HTTHome Television Theatre(A/V technology) HTTHold That Tiger(song title) HTTHonda Tuning Team(The Netherlands) HTTHighly Transportable Terminal ...
In a prospective-longitudinal study of a representative birth cohort, we tested why stressful experiences lead to depression in some people but not in others. A functional polymorphism in the promoter region of the serotonin transporter (5-HTT) gene was found to moderate the influence of stressful...
A key regulator of serotonergic neurotransmission is the serotonin transporter (5-HTT) and a common 5HTT gene promoter polymorphism, termed 5HTTLPR, is associated with phenotypes related to anxiety and depression. Furthermore, the serotonergic system influences hypothalamus–pituitary–adrenal (HPA) axis...
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test)的ANOVA)并且###p0.001(使用Si对照对WT的非配对t测 试)。相对于3个参考基因的几何平均值归一化。 [0220]图8B是描绘单次脑室内注射300μg指示的药剂或aCSF对照后,Q175KI小鼠的脊髓 和纹状体中Htt(小鼠内源性)、内含子1和polyA位点2(1145bp变体)表达的平均荧光强度 (MFI),以及野生型小鼠的脊髓和纹状体...
Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression. Two polymorphic regions of serotonin transporter (5-HTT) gene: a 44 base pair (bp) insertion/deletion in the promoter region (5-HTTLPR) and a 17 bp variabl... D Hranilovic,J ...
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in thehuntingtingene (HTT), which codes for the pathologic mutant HTT (mHTT) protein. Since normal HTT is thought to be important for brain function, we engineered zinc finger ...
Among 751 brains, 6 (0.8%) were diagnosed pathologically as HD and ALS (HD/ALS), exceeding the United States prevalence of ALS (0.0052%, I P i < 0.0001, Fisher's exact test) [[5]]. Recent data have expanded the phenotypic spectrum of Huntington's disease (HD) and the effects of ...