合并结果显示,在有效组的隐性基因模型中,亚洲人群5-HTR1A基因C-1019G多态性与抗抑郁药物疗效有相关性(GGvs.CG+CC,OR=0.751,95%CI为0.585～0.964,P=0.024),中国地区患者5-HTR1A基因C-1019G多态性与抗抑郁药物疗效有相关性(GGvs.CG+CC,OR=0.677,95%CI为0.508～0.901,P=0.007);在缓解组中,5-HTR1A基因C...
结果 HTR1A基因-1019C/G多态性,病例组G等位基因的频率(74.3%)明显高于对照组(65.6%)(P〈0.05).病例组HAMD总分各基因型组间总体比较差异有统计学意义(P〈0.05),C/C基因型组高于C/G,G/G基因型组(P〈0.05).氟西汀治疗6周末,各基因型之间疗效比较差异无统计学意义,不同性别患者各基因型之间疗效比较差异无...
Additionally, most studies have focused on 2 polymorphisms--rs6295 (−1019G/C) in the promoter region and rs878567 (*287 T/C/G) located in the 3’-UTR of the human HTR1A gene. It has been reported that the G allele of rs6295 up-regulates the expression of the 5-HT1A receptor...
et al. The -1019 C/G polymorphism of the 5-HT(1)A receptor gene is associated with negative symptom response to risperidone treatment in schizophrenia patients. J Psychopharmacol 22, 904–909 (2008). 26. Goodfellow, N. M., Benekareddy, M., Vaidya, V. A. & Lambe, E. K. Layer II...
The functional -1019C/G HTR1A polymorphism and mechanisms of fear. Transl Psychiatry 2014; 4: e490 [PMID: 25514753 DOI: 10.1038/tp.2014.130]Straube B, Reif A, Richter J, Lueken U, Weber H, Arolt V et al. The functional -1019C/G HTR1A polymorphism and mechanisms of fear. Transl ...
Several studies have indicated that function-impairing polymorphisms of the serotonin (5-HT) system, such as the serotonin-transporter-linked polymorphic region (5-HTTLPR), 5-HT receptor 1A gene (5-HTR1A) C-1019G and 5-HT receptor 2A gene (5-HTR2A) G-1438A, are likely to be involved ...
P.1.a.009 Impulsivity and the C(-1019)G functional polymorphism of the HTR1A geneThis paper serves to encourage quantum physicists to engage in psychiatric based research on the brain and its functions (i.e., consciousness, memory, attention). By using physics theorems such as Einstein's ...
5-HTR1A geneC-1019G polymorphismMETA-ANALYSISBACKGROUND Major depressive disorder(MDD)is a substantial global health concern,and its treatment is complicated by the variability in individual response to antide-pressants.AIM To consolidate research and clarify the impact of genetic variation on MDD ...
R.MasuzawaN.FukuiSugaiPSYCHIATRY RESEARCHEgawa, J., Endo, T., Tamura, R., Masuzawa, N., Fukui, N., Sugai, T., and Someya, T. (2012). "Influence of the 5-HTR1A C-1019G polymorphism on clinical phenotypes of autism spectrum disorders." Psychiatry Res, 198(2), 336-7....
OPEN Citation: Transl Psychiatry (2014) 4, e490; doi:10.1038/tp.2014.130 www.nature.com/tp ORIGINAL ARTICLE The functional − 1019C/G HTR1A polymorphism and mechanisms of fear B Straube1,13, A Reif2,13, J Richter3,13, U Lueken4, H Weber3, V Arolt5, A Jansen1, P Zwanzger5, ...