合并结果显示,在有效组的隐性基因模型中,亚洲人群5-HTR1A基因C-1019G多态性与抗抑郁药物疗效有相关性(GGvs.CG+CC,OR=0.751,95%CI为0.585～0.964,P=0.024),中国地区患者5-HTR1A基因C-1019G多态性与抗抑郁药物疗效有相关性(GGvs.CG+CC,OR=0.677,95%CI为0.508～0.901,P=0.007);在缓解组中,5-HTR1A基因C...
OPEN Citation: Transl Psychiatry (2014) 4, e490; doi:10.1038/tp.2014.130 www.nature.com/tp ORIGINAL ARTICLE The functional − 1019C/G HTR1A polymorphism and mechanisms of fear B Straube1,13, A Reif2,13, J Richter3,13, U Lueken4, H Weber3, V Arolt5, A Jansen1, P Zwanzger5, ...
et al. The -1019 C/G polymorphism of the 5-HT(1)A receptor gene is associated with negative symptom response to risperidone treatment in schizophrenia patients. J Psychopharmacol 22, 904–909 (2008). 26. Goodfellow, N. M., Benekareddy, M., Vaidya, V. A. & Lambe, E. K. Layer II...
Additionally, most studies have focused on 2 polymorphisms--rs6295 (−1019G/C) in the promoter region and rs878567 (*287 T/C/G) located in the 3’-UTR of the human HTR1A gene. It has been reported that the G allele of rs6295 up-regulates the expression of the 5-HT1A receptor...