近日,暨南大学生命科学技术学院教授王一飞团队研究揭示阿尔茨海默病(AD)的小胶质细胞高表达Mamdc2基因,该基因促进了嗜神经病毒感染诱导的抗病毒天然免疫反应,为理解AD和单纯疱疹病毒1型(HSV-1)之间的联系机制提供了新线索。相关研究发表于Journal of Infection。 AD的病毒感染性假说早已得到认可,HSV-1是与AD密切相关...
Another interesting fact is the existence of a significant degree of homology between HSV1 components and AD susceptibility genes. In this review we summarize findings that reveal connections between the two conditions, as well as different suggestions for the mechanisms of HSV1-induced AD. As most...
疱疹病毒种类 疱疹病毒科是一类大型、双链DNA包膜病毒,分为α、β、γ三个亚家族。已知的九种人类疱疹病毒中,单纯疱疹病毒1型(HSV-1)、单纯疱疹病毒2型(HSV-2)以及水痘带状疱疹病毒(VZV)属于α亚家族,人…
HSV-1-induced IFN-λ, IL-10 and IL-1β as well as the expression of viral IE, E and L genes were analyzed in vitro in peripheral blood mononuclear cells (PBMC) of AD and PD patients as well as of healthy controls (HC). Methods PBMC of AD, PD and HC were in vitro infected ...
本研究对一名接受造血干细胞移植且长有严重舌乳头瘤状赘生物的患者粪便和赘生物组织样本进行了病毒宏基因组学分析。结果显示,两种样本中均含有大量的腺相关病毒2型(AAV2)序列,同时,粪便和组织样本中分别含有大量的可作为AAV2潜在辅助病...
在临床上,HSV-1主要与口面部病变有关,但它也是发达国家感染性失明和成人病毒性脑炎的主要原因。初次感染后,HSV-1潜伏在三叉神经节中,再激活导致不同的免疫病理,可能引起神经元损伤和阿尔茨海默氏病(AD)。 模式识别受体(PRRs)对病毒入侵的早期检测对于诱导快速有效的先天免疫应答至关重要。胞质DNA传感器是最近描述的PR...
目的对单纯疱疹病毒I型(herpes simplex virus type I,HSV-1)与阿尔茨海默病(alzheimer's disease,AD)的病理关系,可能机制及中药抗HSV-1感染研究进行综述.方法检索CNKI... 李舒冉,郭姗姗,崔晓兰 - 《中国药物警戒》 被引量: 0发表: 2023年 与阿尔茨海默病相关的感染性病原体的研究进展 1 (HSV-1),Chlamydo...
Intraocular administration of Ad.VP22-GFP in the rat doubled both the retinal area containing transduced, GFP-expressing cells and the absolute number of GFP-expressing retinal neurons compared to Ad.GFP transduction. Following injection of Ad.VP22-GFP into the mouse brain, the transduced striatal...
The antiviral activity of sulfated fucans from five brown algae (Scytothamnus australis, Marginariella boryana, Papenfussiella lutea, Splachnidium rugosum and Undaria pinnatifida) was investigated in relation to the HSV1-induced formation of beta-amyloid, and AD-like tau. Antiviral activity was ...
It is tempting to speculate that intra- and extracellular accumulation of these species in the CNS resulting from repeated HSV-1 reactivation could, in the presence of other risk factors, play a co-factorial role in the development of AD. 展开 ...