(2006) Activa- tion of the HSV-TK promoter in control reporter vector pBLCAT5 by liganded nuclear retinoid receptor RXRalpha. Arch. Biol. Sci. Belgrade 58, 197-203.NIKCEVIC G, KOVACEVIC GRUJICIC N, STEVANOVIC M: Activation of the HSV- TK promoter in control reporter vector pBLCAT5 by ...
(EBV)-associated cancer by employing the suicide gene, herpes simplex virus thymidine kinase/ganciclovir (HSV-tk/GCV), which uses the signaling pathway through the HIV-long terminal repeat (LTR) gene which is expressed from a nuclear factor-κB (NF-κB)-binding motif-containing promoter that ...
目的:分别构建人乳腺珠蛋白(human mammaglobin,hMAM)基因增强子和启动子(enhancer and promoter ofhMAM,hMAM-EP)调控的增强型绿色荧光蛋白(enhanced green fluorescent protein,EGFP)报告基因和单纯疱疹病毒胸苷激酶(herpes simple virus thymidine kinase,HSV-TK)自杀基因两种重组腺病毒载体,探讨hMAM-EP调控的HSV-TK在乳腺...
promoter 67..85 /label=SP6 promoter /note="promoter for bacteriophage SP6 RNA polymerase" primer_bind 67..84 /label=SP6 /note="SP6 promoter, forward primer" primer_bind complement(220..239) /label=T7 /note="T7 promoter, forward primer" promoter complement(221..239) /label=T7 promoter ...
The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter. Telomerase, the enzyme that synthesizes telomeric DNA, is not expressed in most human somatic cells but is activated with in vitro immortalization and duri... Y,S,Cong,... - 《Human Mol...
genepromoter Abstract Objectives:To establishthe correlated eukaryoticexpression vectorofHSV-tk,and transfecttherecombinanttotumorcell throughlipidosome,then observethe killing effectof HSV4k/GCV system on hepatoma c盯cmomacell underthe controlofhTERT(human ...
HSV-TK/GCV induced by the retroviral vectors, which were driven by promoter had a certain effect on prevention and treat of GVHD. The effect of prophylactic administration in early period after transplantation was better than therapeutic administration when GVHD had occurred. 展开 ...
To this end, we expressed these protein systems from a minimal promoter in combination with five copies of the HRE derived from the human VEGF enhancer. Through extensive testing using both hypoxia drug mimetics and true hypoxia, we have observed tightly regulated hypoxia-dependent cancer cell ...
The promoter of Egr1, a transcrip- tion factor regulating early cell growth, can induce the expression of its downstream genes after ionizing radi- ation, thereby attaining a spatio-temporal regulation on the target gene expression. Notable achievements in radiation-gene therapy have been obtained ...
Cell growth- and P53-dependent transcriptional activity of the midkine promoter confers suicide gene expression in tumor cells. HSV-TKP53suicide geneMidkine (MK) is preferentially expressed in a number of human tumors, while the expression in adult normal tissues is restricted. ... L Yu,SI Ugai...