Activation of the HSV-TK promoter in control reporter vector pBLCAT5 by liganded nuclear retinoid receptor RXRalpha. Arch. Biol. Sci. (Belgrade) 58, 197-203.NIKCEVIC G, KOVACEVIC GRUJICIC N, STEVANOVIC M: Activation of the HSV- TK promoter in control reporter vector pBLCAT5 by liganded ...
NV1020 R7020 ICP0,ICP4,ICP34.5单拷贝缺失,UL56缺失,TK替换成为HSV-2 TK rQNestin 34.5 F ICP34.5前加了nestin promoter M032 F ICP34.5双拷贝缺失,并在此位点表达IL-12。 ONCR-177 ONCR-159 ICP34.5单拷贝缺失,引入组织特异性miRNA调控ICP34.5的表达;UL37 突变;插入IL12, FLT3LG, CCL4, PD-1拮抗剂...
目的:分别构建人乳腺珠蛋白(human mammaglobin,hMAM)基因增强子和启动子(enhancer and promoter ofhMAM,hMAM-EP)调控的增强型绿色荧光蛋白(enhanced green fluorescent protein,EGFP)报告基因和单纯疱疹病毒胸苷激酶(herpes simple virus thymidine kinase,HSV-TK)自杀基因两种重组腺病毒载体,探讨hMAM-EP调控的HSV-TK在乳腺...
(EBV)-associated cancer by employing the suicide gene, herpes simplex virus thymidine kinase/ganciclovir (HSV-tk/GCV), which uses the signaling pathway through the HIV-long terminal repeat (LTR) gene which is expressed from a nuclear factor-κB (NF-κB)-binding motif-containing promoter that ...
[0033] 与HI 29-BAC相比,变体病毒HI 29-GFP-BAC、HI 29-mGFP-BAC的GFP表达信号更强,应 用更方便;CMV-p为CMV的promoter序列;GFP基因为Gene ID为20473140;mGFP通过以pCAG-mGFP(Addgene公司,货号为14757)为模板扩增得到。[0034] 如上所述的I型单纯疱疹病毒H129-BAC的变体病毒的构建方法,包括:[0035] 1)...
质粒名称: pHSV-TK 出品公司: Addgene 目录编号: 165801 存储实验室: Koen Venken 载体骨架基本信息 载体名称: pUPD2 载体出品公司: Clontech 空载体大小: 2955bp 完整质粒大小: 4989 bp 载体类型: Insect Expression 载体抗性: 氨苄霉素 生长温度: 37 ℃ 宿主菌: DH10B 拷贝数: 高拷贝 插入基因信息 插入基...
现有的临床试验显示,HSV-TK/GCV治疗方案的副作用多,尽管大多数比较轻;而且有动物实验显示,HSV-TK/GCV治疗系统有导致严重肝损害的可能.因此,HSV-TK/GCV治疗方案的临床应用,仍存在不容忽视的潜在风险.肿瘤基因治疗的理想结果是,目的基因表达对肿瘤细胞产生尽可能强的杀伤作用,同时又避免对正常细胞的毒性反应.靶向性...
As our method for achieving hypoxia-specific expression for HSV-tk and Cas9 requires transcriptional activation at the promoter level, we needed a vehicle that could facilitate delivery of a DNA-based system in order to achieve regulated expression of these genes. While AAV has been widely used ...
13.The selective killing effect of adenoviral mediated HSV-TK/GCV suicide gene system on prostate cancer cells腺病毒介导HSV-TK/GCV自杀基因系统靶向性治疗前列腺癌实验研究 14.Effect of Adenovirus Mediated HSV-tk+GCV Genic System Controlled by HTERT Promoter on the Treatment of Mouse Xenografts Model ...
【Keywords】 telomerase; promoter regions (genetics); cervix neoplasms; tk gene 【摘要】目的: 研究人端粒酶逆转录酶(hTERT)基因核心启动子调控的人单纯疱疹病毒胸苷激酶基因/更昔洛韦(HSVtk/GCV)系统对宫颈癌细胞的体外杀伤作用.方法: 构建hTERT基因启动子调控的tk基因真核表达载体pCIneo/hTERTtk,分别用脂质体法转...